BROWSE

Related Researcher

Author's Photo

Min, Kyung-Tai
Molecular & Cellular Neurobiology Lab(Min Lab)
Research Interests
  • adult neurogenesis; axon development; axon regeneration; protein stability; protein synthesis; Down syndrome; Alzheimer's disease;

ITEM VIEW & DOWNLOAD

IRES‐mediated translation of cofilin regulates axonal growth cone extension and turning

Cited 0 times inthomson ciCited 0 times inthomson ci
Title
IRES‐mediated translation of cofilin regulates axonal growth cone extension and turning
Author
Choi, Jung-HyunWang, WeiPark, DongkeunKim, Sung-HoonKim, Kyong-TaiMin, Kyung-Tai
Issue Date
2018-03
Publisher
WILEY-BLACKWELL
Citation
EMBO JOURNAL, v.37, no.5, pp.e95266
Abstract
In neuronal development, dynamic rearrangement of actin promotes axonal growth cone extension, and spatiotemporal translation of local mRNAs in response to guidance cues directs axonal growth cone steering, where cofilin plays a critical role. While regulation of cofilin activity is well studied, regulatory mechanism for cofilin mRNA translation in neurons is unknown. In eukaryotic cells, proteins can be synthesized by cap‐dependent or cap‐independent mechanism via internal ribosome entry site (IRES)‐mediated translation. IRES‐mediated translation has been reported in various pathophysiological conditions, but its role in normal physiological environment is poorly understood. Here, we report that 5′UTR of cofilin mRNA contains an IRES element, and cofilin is predominantly translated by IRES‐mediated mechanism in neurons. Furthermore, we show that IRES‐mediated translation of cofilin is required for both axon extension and axonal growth cone steering. Our results provide new insights into the function of IRES‐mediated translation in neuronal development.
URI
https://scholarworks.unist.ac.kr/handle/201301/23701
URL
http://emboj.embopress.org/content/37/5/e95266
DOI
10.15252/embj.201695266
ISSN
0261-4189
Appears in Collections:
SLS_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU