There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.number | 5 | - |
dc.citation.startPage | e95266 | - |
dc.citation.title | EMBO JOURNAL | - |
dc.citation.volume | 37 | - |
dc.contributor.author | Choi, Jung-Hyun | - |
dc.contributor.author | Wang, Wei | - |
dc.contributor.author | Park, Dongkeun | - |
dc.contributor.author | Kim, Sung-Hoon | - |
dc.contributor.author | Kim, Kyong-Tai | - |
dc.contributor.author | Min, Kyung-Tai | - |
dc.date.accessioned | 2023-12-21T21:07:57Z | - |
dc.date.available | 2023-12-21T21:07:57Z | - |
dc.date.created | 2018-02-27 | - |
dc.date.issued | 2018-03 | - |
dc.description.abstract | In neuronal development, dynamic rearrangement of actin promotes axonal growth cone extension, and spatiotemporal translation of local mRNAs in response to guidance cues directs axonal growth cone steering, where cofilin plays a critical role. While regulation of cofilin activity is well studied, regulatory mechanism for cofilin mRNA translation in neurons is unknown. In eukaryotic cells, proteins can be synthesized by cap‐dependent or cap‐independent mechanism via internal ribosome entry site (IRES)‐mediated translation. IRES‐mediated translation has been reported in various pathophysiological conditions, but its role in normal physiological environment is poorly understood. Here, we report that 5′UTR of cofilin mRNA contains an IRES element, and cofilin is predominantly translated by IRES‐mediated mechanism in neurons. Furthermore, we show that IRES‐mediated translation of cofilin is required for both axon extension and axonal growth cone steering. Our results provide new insights into the function of IRES‐mediated translation in neuronal development. | - |
dc.identifier.bibliographicCitation | EMBO JOURNAL, v.37, no.5, pp.e95266 | - |
dc.identifier.doi | 10.15252/embj.201695266 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.scopusid | 2-s2.0-85041803810 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/23701 | - |
dc.identifier.url | http://emboj.embopress.org/content/37/5/e95266 | - |
dc.identifier.wosid | 000426527000001 | - |
dc.language | 영어 | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | IRES‐mediated translation of cofilin regulates axonal growth cone extension and turning | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | axonal growth cone | - |
dc.subject.keywordAuthor | cofilin | - |
dc.subject.keywordAuthor | internal ribosome entry sites | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | INTERNAL INITIATION | - |
dc.subject.keywordPlus | RHYTHMIC CONTROL | - |
dc.subject.keywordPlus | ACTIN-FILAMENT | - |
dc.subject.keywordPlus | LIM-KINASE | - |
dc.subject.keywordPlus | HNRNP-Q | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | DYNAMICS | - |
dc.subject.keywordPlus | MORPHOGENESIS | - |
dc.subject.keywordPlus | ADF/COFILIN | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.