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- Scharer, Orlando D.
- Schärer Lab.
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Preparation of C8-amine and acetylamine adducts of 2 '-deoxyguanosine suitably protected for DNA synthesis
- Author(s)
- Gillet, Ludovic C. J., Scharer, Orlando D.
- Issued Date
- 2002-11
- Citation
- ORGANIC LETTERS, v.4, no.24, pp.4205 - 4208
- Abstract
- C8-Amine and acetylamine adducts of 2'-deoxyguanosine were synthesized. Our approach provides solutions for the coupling of aromatic amines to a protected 8-bromo-2'-deoxyguanosine derivative, for the selective acetylation of the coupled adduct at N-8 and for a protecting group scheme preserving the integrity of the base-labile N-8 acetyl group during DNA synthesis.
- Publisher
- AMER CHEMICAL SOC
- ISSN
- 1523-7060
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