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- Scharer, Orlando D.
- Schärer Lab.
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A molecular basis for damage recognition in eukaryotic nucleotide excision repair
- Author(s)
- Schaerer, Orlando D.
- Issued Date
- 2008-01
- Citation
- CHEMBIOCHEM, v.9, no.1, pp.21 - 23
- Abstract
- How to spot a lesion. A recent report from Min and Pavletich provides a molecular basis for how a variety of structurally diverse lesions are recognized in eukaryotic nucleotide excision repair. The initial damage sensor XPC/HR23B probes the DNA helix for thermodynamically destabilized sites and interacts with undamaged nucleotides opposite a DNA lesion.
- Publisher
- WILEY-V C H VERLAG GMBH
- ISSN
- 1439-4227
- Keyword (Author)
- DNA damage, DNA repair, molecular recognition, xeroderma pigmentosum, X-ray crystallography
- Keyword
- C PROTEIN COMPLEX, DNA-DAMAGE, MECHANISM, DISCRIMINATION, TRANSCRIPTION, STRAND, CELLS, TFIIH
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