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- Scharer, Orlando D.
- Schärer Lab.
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Wedging out DNA damage
- Author(s)
- Scharer, Orlando D., Campbell, Arthur J.
- Issued Date
- 2009-02
- Citation
- NATURE STRUCTURAL & MOLECULAR BIOLOGY, v.16, no.2, pp.102 - 104
- Abstract
- The DNA-repair machinery is faced with the significant challenge of differentiating DNA lesions from unmodified DNA. Two recent publications, one in this issue of Nature Structural & Molecular Biology, uncover a new way of recognizing minimally distorting DNA lesions: insertion of a 3- or 4-amino-acid wedge into DNA to extrude the lesion into a shallow binding pocket that can accommodate various damaged bases.
- Publisher
- NATURE PUBLISHING GROUP
- ISSN
- 1545-9993
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