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- Scharer, Orlando D.
- Schärer Lab.
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Synthesis and Molecular Modeling of a Nitrogen Mustard DNA Interstrand Crosslink
- Author(s)
- Guainazzi, Angelo, Campbell, Arthur J., Angelov, Todor, Simmerling, Carlos, Schaerer, Orlando D.
- Issued Date
- 2010-10
- Citation
- CHEMISTRY-A EUROPEAN JOURNAL, v.16, no.40, pp.12100 - 12103
- Abstract
- Nitrogen mustard reloaded: Over 60 years after nitrogen mustards (NMs) were the first agents used to treat tumors by chemotherapy, we provide a method to generate the main DNA adduct formed by NMs and validate them by using molecular dynamics simulations (see graphic). We are able to provide amounts that permit extensive structural and biological studies.
- Publisher
- WILEY-V C H VERLAG GMBH
- ISSN
- 0947-6539
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