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Kim, Jiyun
School of Materials Science and Engineering
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Colour-barcoded magnetic microparticles for multiplexed bioassays

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Title
Colour-barcoded magnetic microparticles for multiplexed bioassays
Author
Lee, HowonKim, JunhoiKim, HyokiKim, JiyunKwon, Sunghoon
Issue Date
2010-09
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE MATERIALS, v.9, no.9, pp.745 - 749
Abstract
Encoded particles have a demonstrated value for multiplexed high-throughput bioassays such as drug discovery and clinical diagnostics(1,2). In diverse samples, the ability to use a large number of distinct identification codes on assay particles is important to increase throughput(3). Proper handling schemes are also needed to readout these codes on free-floating probe microparticles. Here we create vivid, free-floating structural coloured particles with multi-axis rotational control using a colour-tunable magnetic material and a new printing method(4). Our colour-barcoded magnetic microparticles offer a coding capacity easily into the billions with distinct magnetic handling capabilities including active positioning for code readouts and active stirring for improved reaction kinetics in microscale environments(5). A DNA hybridization assay is done using the colour-barcoded magnetic microparticles to demonstrate multiplexing capabilities
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DOI
10.1038/NMAT2815
ISSN
1476-1122
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MSE_Journal Papers
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