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Kim, Jiyun
School of Materials Science and Engineering
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Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models

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Title
Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models
Author
Kim, JiyunTanner, Kandice
Keywords
tumor microenvironment; 3D culture models; ecology; biomaterials and nanotechnology; hydrogels
Issue Date
2015-07
Publisher
Frontiers Media S. A.
Citation
FRONTIERS IN ONCOLOGY, v.5, no., pp.170 -
Abstract
Advances in cancer research have shown that a tumor can be likened to a foreign species that disrupts delicately balanced ecological interactions, compromising the survival of normal tissue ecosystems. In efforts to mitigate tumor expansion and metastasis, experimental approaches from ecology are becoming more frequently and successfully applied by researchers from diverse disciplines to reverse engineer and re-engineer biological systems in order to normalize the tumor ecosystem. We present a review on the use of 3D biomimetic platforms to recapitulate biotic and abiotic components of the tumor ecosystem, in efforts to delineate the underlying mechanisms that drive evolution of tumor heterogeneity, tumor dissemination, and acquisition of drug resistance.
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DOI
10.3389/fonc.2015.00170
ISSN
2234-943X
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MSE_Journal Papers
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