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김정범

Kim, Jeong Beom
Molecular Biomedicine Lab.
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Induced neural stem cells from distinct genetic backgrounds exhibit different reprogramming status

Author(s)
Kim, Sung MinLim, Kyung TaeKwak, Tae HwanLee, Seung ChanIm, Jung HyunHali, SaiHwang, Seon InKim, DajeongHwang, JeonghoKim, Kee PyoChung, Hak JaeKim, Jeong BeomKo, KinarmChung, Hyung MinLee, Hoon TaekScholer, Hans R.Han, Dong Wook
Issued Date
2016-03
DOI
10.1016/j.scr.2016.02.025
URI
https://scholarworks.unist.ac.kr/handle/201301/18817
Fulltext
http://www.sciencedirect.com/science/article/pii/S1873506116000672
Citation
STEM CELL RESEARCH, v.16, no.2, pp.460 - 468
Abstract
Somatic cells could be directly converted into induced neural stem cells (iNSCs) by ectopic expression of defined transcription factors. However, the underlying mechanism of direct lineage transition into iNSCs is largely unknown. In this study, we examined the effect of genetic background on the direct conversion process into an iNSC state. The iNSCs from two different mouse strains exhibited the distinct efficiency of lineage conversion as well as clonal expansion. Furthermore, the expression levels of endogenous NSC markers, silencing of transgenes, and in vitro differentiation potential were also different between iNSC lines from different strains. Therefore, our data suggest that the genetic background of starting cells influences the conversion efficiency as well as reprogramming status of directly converted iNSCs.
Publisher
ELSEVIER SCIENCE BV
ISSN
1873-5061
Keyword (Author)
Genetic backgroundsDirect conversionDirect reprogrammingCell fate transitioniNSCs
Keyword
MOUSE FIBROBLASTSDIRECT CONVERSIONGENERATIONINDUCTIONCARDIOMYOCYTESPLURIPOTENCYINTEGRATIONFACILITATEOCT4

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