Full metadata record
DC Field | Value | Language |
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dc.citation.endPage | 468 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 460 | - |
dc.citation.title | STEM CELL RESEARCH | - |
dc.citation.volume | 16 | - |
dc.contributor.author | Kim, Sung Min | - |
dc.contributor.author | Lim, Kyung Tae | - |
dc.contributor.author | Kwak, Tae Hwan | - |
dc.contributor.author | Lee, Seung Chan | - |
dc.contributor.author | Im, Jung Hyun | - |
dc.contributor.author | Hali, Sai | - |
dc.contributor.author | Hwang, Seon In | - |
dc.contributor.author | Kim, Dajeong | - |
dc.contributor.author | Hwang, Jeongho | - |
dc.contributor.author | Kim, Kee Pyo | - |
dc.contributor.author | Chung, Hak Jae | - |
dc.contributor.author | Kim, Jeong Beom | - |
dc.contributor.author | Ko, Kinarm | - |
dc.contributor.author | Chung, Hyung Min | - |
dc.contributor.author | Lee, Hoon Taek | - |
dc.contributor.author | Scholer, Hans R. | - |
dc.contributor.author | Han, Dong Wook | - |
dc.date.accessioned | 2023-12-22T00:08:00Z | - |
dc.date.available | 2023-12-22T00:08:00Z | - |
dc.date.created | 2016-03-17 | - |
dc.date.issued | 2016-03 | - |
dc.description.abstract | Somatic cells could be directly converted into induced neural stem cells (iNSCs) by ectopic expression of defined transcription factors. However, the underlying mechanism of direct lineage transition into iNSCs is largely unknown. In this study, we examined the effect of genetic background on the direct conversion process into an iNSC state. The iNSCs from two different mouse strains exhibited the distinct efficiency of lineage conversion as well as clonal expansion. Furthermore, the expression levels of endogenous NSC markers, silencing of transgenes, and in vitro differentiation potential were also different between iNSC lines from different strains. Therefore, our data suggest that the genetic background of starting cells influences the conversion efficiency as well as reprogramming status of directly converted iNSCs. | - |
dc.identifier.bibliographicCitation | STEM CELL RESEARCH, v.16, no.2, pp.460 - 468 | - |
dc.identifier.doi | 10.1016/j.scr.2016.02.025 | - |
dc.identifier.issn | 1873-5061 | - |
dc.identifier.scopusid | 2-s2.0-84959323426 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/18817 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1873506116000672 | - |
dc.identifier.wosid | 000375562600058 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Induced neural stem cells from distinct genetic backgrounds exhibit different reprogramming status | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology | - |
dc.relation.journalResearchArea | Cell Biology; Biotechnology & Applied Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Genetic backgrounds | - |
dc.subject.keywordAuthor | Direct conversion | - |
dc.subject.keywordAuthor | Direct reprogramming | - |
dc.subject.keywordAuthor | Cell fate transition | - |
dc.subject.keywordAuthor | iNSCs | - |
dc.subject.keywordPlus | MOUSE FIBROBLASTS | - |
dc.subject.keywordPlus | DIRECT CONVERSION | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | CARDIOMYOCYTES | - |
dc.subject.keywordPlus | PLURIPOTENCY | - |
dc.subject.keywordPlus | INTEGRATION | - |
dc.subject.keywordPlus | FACILITATE | - |
dc.subject.keywordPlus | OCT4 | - |
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