BROWSE

Related Researcher

Author's Photo

Myung, Kyungjae
Center for Genomic Integrity
Research Interests
  • DNA Replication, DNA Repair, DNA Recombination, DNA Damage Response, cancer, aging

ITEM VIEW & DOWNLOAD

A novel role for the mono-ADP-ribosyltransferase PARP14/ATRD8 in promoting homologous recombination and protecting against replication stress

Cited 0 times inthomson ciCited 0 times inthomson ci
Title
A novel role for the mono-ADP-ribosyltransferase PARP14/ATRD8 in promoting homologous recombination and protecting against replication stress
Author
Nicolae, Claudia M.Aho, Erin R.Choe, Katherine N.Lee, DeokjaeMyung, KyungjaeMoldovan, George-Lucian
Keywords
nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 14; protein ARTD8; Rad51 protein; small interfering RNA; unclassified drug
Issue Date
2015-03
Publisher
OXFORD UNIV PRESS
Citation
NUCLEIC ACIDS RESEARCH, v.43, no.6, pp.3143 - 3153
Abstract
Genomic instability, a major hallmark of cancer cells, is caused by incorrect or ineffective DNA repair. Many DNA repair mechanisms cooperate in cells to fight DNA damage, and are generally regulated by post-translational modification of key factors. Poly-ADP-ribosylation, catalyzed by PARP1, is a post-translational modification playing a prominent role in DNA repair, but much less is known about mono-ADP-ribosylation. Here we report that mono-ADP-ribosylation plays an important role in homologous recombination DNA repair, a mechanism essential for replication fork stability and double strand break repair. We show that the mono-ADP-ribosyltransferase PARP14 interacts with the DNA replication machinery component PCNA and promotes replication of DNA lesions and common fragile sites. PARP14 depletion results in reduced homologous recombination, persistent RAD51 foci, hypersensitivity to DNA damaging agents and accumulation of DNA strand breaks. Our work uncovered PARP14 as a novel factor required for mitigating replication stress and promoting genomic stability.
URI
Go to Link
DOI
10.1093/nar/gkv147
ISSN
0305-1048
Appears in Collections:
BME_Journal Papers
Files in This Item:
2015NAR.pdf Download

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU