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Ko, Myunggon
Molecular Immunology & Cancer Epigenetics
Research Interests
  • TET proteins, DNA hydroxymethylation, oncogenesis, cancer stem cells, cancer therapy

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Acute loss of TET function results in aggressive myeloid cancer in mice

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Title
Acute loss of TET function results in aggressive myeloid cancer in mice
Author
An, JungeunGonzalez-Avalos, E.Chawla, AshuJeong, MiraLopez-Moyado, Isaac F.Li, WeiGoodell, Margaret A.Chavez, LukasKo, MyunggonRao, Anjana
Issue Date
2015-11
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE COMMUNICATIONS, v.6, pp.10071
Abstract
TET-family dioxygenases oxidize 5-methylcytosine (5mC) in DNA, and exert tumour suppressor activity in many types of cancers. Even in the absence of TET coding region mutations, TET loss-of-function is strongly associated with cancer. Here we show that acute elimination of TET function induces the rapid development of an aggressive, fully-penetrant and cell-autonomous myeloid leukaemia in mice, pointing to a causative role for TET loss-of-function in this myeloid malignancy. Phenotypic and transcriptional profiling shows aberrant differentiation of haematopoietic stem/progenitor cells, impaired erythroid and lymphoid differentiation and strong skewing to the myeloid lineage, with only a mild relation to changes in DNA modification. We also observe progressive accumulation of phospho-H2AX and strong impairment of DNA damage repair pathways, suggesting a key role for TET proteins in maintaining genome integrity
URI
https://scholarworks.unist.ac.kr/handle/201301/17940
URL
http://www.nature.com/ncomms/2015/151126/ncomms10071/full/ncomms10071.html
DOI
10.1038/ncomms10071
ISSN
2041-1723
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BIO_Journal Papers
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