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Kim, Sung Youb
Computational Advanced Nanomechanics (CAN) Lab
Research Interests
  • Computational Mechanics
  • Nanomechanics
  • Molecular Dynamics
  • FEM

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Multiphysics and Multiscale Analysis for Chemotherapeutic Drug

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Title
Multiphysics and Multiscale Analysis for Chemotherapeutic Drug
Author
Zhang, LinanKim, Sung YoubKim, Dongchoul
Issue Date
2015-08
Publisher
Hindawi Pub. Corp.
Citation
BIOMED RESEARCH INTERNATIONAL, v.2015, pp.493985
Abstract
This paper presents a three-dimensional dynamic model for the chemotherapy design based on a multiphysics and multiscale approach. Themodel incorporates cancer cells, matrix degrading enzymes (MDEs) secreted by cancer cells, degrading extracellular matrix (ECM), and chemotherapeutic drug. Multiple mechanisms related to each component possible in chemotherapy are systematically integrated for high reliability of computational analysis of chemotherapy. Moreover, the fidelity of the estimated efficacy of chemotherapy is enhanced by atomic information associated with the diffusion characteristics of chemotherapeutic drug, which is obtained from atomic simulations. With the developed model, the invasion process of cancer cells in chemotherapy treatment is quantitatively investigated. The performed simulations suggest a substantial potential of the presented model for a reliable design technology of chemotherapy treatment
URI
https://scholarworks.unist.ac.kr/handle/201301/17684
URL
http://www.hindawi.com/journals/bmri/2015/493985/
DOI
10.1155/2015/493985
ISSN
2314-6133
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