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Kim, Sung Youb
Computational Advanced Nanomechanics (CAN) Lab
Research Interests
  • Computational Mechanics
  • Nanomechanics
  • Molecular Dynamics
  • FEM

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Multiphysics and Multiscale Analysis for Chemotherapeutic Drug

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dc.contributor.author Zhang, Linan ko
dc.contributor.author Kim, Sung Youb ko
dc.contributor.author Kim, Dongchoul ko
dc.date.available 2015-11-03T06:34:11Z -
dc.date.created 2015-11-03 ko
dc.date.issued 2015-08 ko
dc.identifier.citation BIOMED RESEARCH INTERNATIONAL, v.2015, pp.493985 ko
dc.identifier.issn 2314-6133 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/17684 -
dc.description.abstract This paper presents a three-dimensional dynamic model for the chemotherapy design based on a multiphysics and multiscale approach. Themodel incorporates cancer cells, matrix degrading enzymes (MDEs) secreted by cancer cells, degrading extracellular matrix (ECM), and chemotherapeutic drug. Multiple mechanisms related to each component possible in chemotherapy are systematically integrated for high reliability of computational analysis of chemotherapy. Moreover, the fidelity of the estimated efficacy of chemotherapy is enhanced by atomic information associated with the diffusion characteristics of chemotherapeutic drug, which is obtained from atomic simulations. With the developed model, the invasion process of cancer cells in chemotherapy treatment is quantitatively investigated. The performed simulations suggest a substantial potential of the presented model for a reliable design technology of chemotherapy treatment ko
dc.description.statementofresponsibility open -
dc.language 영어 ko
dc.publisher Hindawi Pub. Corp. ko
dc.title Multiphysics and Multiscale Analysis for Chemotherapeutic Drug ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84944219898 ko
dc.identifier.wosid 000362752800001 ko
dc.type.rims ART ko
dc.description.wostc 0 *
dc.date.tcdate 2015-12-28 *
dc.identifier.doi 10.1155/2015/493985 ko
dc.identifier.url http://www.hindawi.com/journals/bmri/2015/493985/ ko
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