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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Overexpression of phospholipase C-gamma 1 in rat 3Y1 fibroblast cells leads to malignant transformation

Cited 47 times inthomson ciCited 49 times inthomson ci
Title
Overexpression of phospholipase C-gamma 1 in rat 3Y1 fibroblast cells leads to malignant transformation
Author
Chang, Jong-SooNoh, Dong YoungPark, In AeKim, Myung JongSong, HebokRyu, Sung HoSuh, Pann-Ghill
Issue Date
1997-12
Publisher
AMER ASSOC CANCER RESEARCH
Citation
CANCER RESEARCH, v.57, no.24, pp.5465 - 5468
Abstract
Phospholipase C-gamma 1 (PLC-gamma l) mediates signals from various extracellular origins to evoke cellular events such as mitogenesis. Previously, we reported that PLC-gamma 1 was highly expressed in colorectal cancer and familial adenomatous polyposis, suggesting that PLC-gamma 1 might be oncogenic. In this study, we have established rat 3Y1 fibroblasts that overexpress whole PLC-gamma 1 and src homology 2 (SH2)-SH2-SH3 domain of PLC-gamma 1. These cells showed a transformed phenotype and were tumorigenic when transplanted into nude mice. These results indicate that overexpression of PLC-gamma 1 could transform rat fibroblasts, and the transformation is mediated by SH2-SH2-SH3 domain of PLC-gamma 1
URI
https://scholarworks.unist.ac.kr/handle/201301/16490
URL
http://cancerres.aacrjournals.org/content/57/24/5465.long
ISSN
0008-5472
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BIO_Journal Papers
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