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| DC Field | Value | Language |
|---|---|---|
| dc.citation.endPage | 5468 | - |
| dc.citation.number | 24 | - |
| dc.citation.startPage | 5465 | - |
| dc.citation.title | CANCER RESEARCH | - |
| dc.citation.volume | 57 | - |
| dc.contributor.author | Chang, Jong-Soo | - |
| dc.contributor.author | Noh, Dong Young | - |
| dc.contributor.author | Park, In Ae | - |
| dc.contributor.author | Kim, Myung Jong | - |
| dc.contributor.author | Song, Hebok | - |
| dc.contributor.author | Ryu, Sung Ho | - |
| dc.contributor.author | Suh, Pann-Ghill | - |
| dc.date.accessioned | 2023-12-22T12:36:44Z | - |
| dc.date.available | 2023-12-22T12:36:44Z | - |
| dc.date.created | 2015-08-19 | - |
| dc.date.issued | 1997-12 | - |
| dc.description.abstract | Phospholipase C-gamma 1 (PLC-gamma l) mediates signals from various extracellular origins to evoke cellular events such as mitogenesis. Previously, we reported that PLC-gamma 1 was highly expressed in colorectal cancer and familial adenomatous polyposis, suggesting that PLC-gamma 1 might be oncogenic. In this study, we have established rat 3Y1 fibroblasts that overexpress whole PLC-gamma 1 and src homology 2 (SH2)-SH2-SH3 domain of PLC-gamma 1. These cells showed a transformed phenotype and were tumorigenic when transplanted into nude mice. These results indicate that overexpression of PLC-gamma 1 could transform rat fibroblasts, and the transformation is mediated by SH2-SH2-SH3 domain of PLC-gamma 1 | - |
| dc.identifier.bibliographicCitation | CANCER RESEARCH, v.57, no.24, pp.5465 - 5468 | - |
| dc.identifier.issn | 0008-5472 | - |
| dc.identifier.scopusid | 2-s2.0-15644368498 | - |
| dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/16490 | - |
| dc.identifier.url | http://cancerres.aacrjournals.org/content/57/24/5465.long | - |
| dc.identifier.wosid | 000070948600007 | - |
| dc.language | 영어 | - |
| dc.publisher | AMER ASSOC CANCER RESEARCH | - |
| dc.title | Overexpression of phospholipase C-gamma 1 in rat 3Y1 fibroblast cells leads to malignant transformation | - |
| dc.type | Article | - |
| dc.description.journalRegisteredClass | scopus | - |
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