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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Overexpression of phospholipase C beta-1 protects NIH3T3 cells from oxidative stress-induced cell death

Cited 18 times inthomson ciCited 19 times inthomson ci
Title
Overexpression of phospholipase C beta-1 protects NIH3T3 cells from oxidative stress-induced cell death
Author
Lee, Young HanKim, Seong-YongKim, Jae-RyungYoh, Kyu-TongBaek, Suk-HwanKim, Myong JongRyu, Sung HoSuh, Pann-GhillKim, Jung-Hye
Issue Date
2000-07
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
LIFE SCIENCES, v.67, no.7, pp.827 - 837
Abstract
Oxidative stress has been implicated in a wide range of cellular damage which includes DNA oxidation, membrane lipid peroxidation, and apoptosis. In our study, we found that overexpression of PLC-beta 1 in NIH3T3 fibroblasts protected them from cell death occuring in response to oxidative stress. Cell death caused by treatment with prooxidant tert-butylhydroperoxide (TBH), H2O2, or CdCl2 was considerably suppressed in PLC-beta 1 overexpressed NIH/beta 1-14 cells in comparison to control NIH/neo cells. However, overexpression of PLC-beta 1 failed to protect the cells from toxicity by diamide or KCN. In addition, while accumulation of c-fos mRNA was observed within 30 min of TBH treatment in vector transfected NIH/neo cells, TBH-induced c-fos mRNA generation was completely suppressed in NIH/beta 1-14 cells, while that of c-jun and GAPDH was not affected. These findings suggest that PLC-beta 1 may play a role in process that can protect cells from oxidative stress-induced cell death. (C) 2000 Elsevier Science Inc. All rights reserved
URI
https://scholarworks.unist.ac.kr/handle/201301/16481
URL
http://www.sciencedirect.com/science/article/pii/S0024320500006779
DOI
10.1016/S0024-3205(00)00677-9
ISSN
0024-3205
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BIO_Journal Papers
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