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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
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  • Signal transduction, cancer, metabolism, phospholipase C

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Lower absorption of cholesteryl oleate in rats supplemented with Areca catechu L. extract

Cited 7 times inthomson ciCited 12 times inthomson ci
Title
Lower absorption of cholesteryl oleate in rats supplemented with Areca catechu L. extract
Author
Jeon, SMKim, HSLee, TGRyu, SHSuh, PGByun, SJPark, YBChoi, MS
Issue Date
2000-07
Publisher
KARGER
Citation
ANNALS OF NUTRITION AND METABOLISM, v.44, no.4, pp.170 - 176
Abstract
Areca catechu L. extracts I and II, prepared using two different solvent systems, exhibited strong inhibitory activities against pancreatic cholesterol esterase (pCEase) in vitro. To determine their cholesterol-towering effects, these two extracts were investigated by analyzing plasma lipid levels, intestinal enzyme activities, and the absorption of cholesteryl oleate. For 6 days, male rats were fed a diet containing cholesteryl oleate (0.5 g/100 g of body weight) either with or without the Areca nut extract supplements. The supplementation of the two Areca nut extracts significantly lowered the concentrations of plasma cholesterol by 13.4 and 11.7% and plasma triglycerides by 35.0 and 36.9%, respectively, compared with the pre-experimental values. However, when the cholesteryl oleate diet was fed without any Areca nut extract in high-cholesterol control, the plasma cholesterol and triglyceride concentrations significantly increased by 13.6 and 15.9%, respectively, compared with the preexperimental va lues. After 6 days of treatment, the intestinal pCEase activities were significantly lower in the groups supplemented with the Areca nut extracts (37.8 and 26.5%) than in the group with no extract supplement (83.2%). The supplements also significantly elevated the excretion of [1,2(n)-H-3]cholesteryl oleate administered orally, when determined by the large intestinal contents, 930.5 Bq/day (Areca I) and 1,766.3 Bq/day (Areca II) vs. 98.1 Bq/day (high-cholesteryl oleate (CO) control). The inhibition of pCEase activity with the supplementation of the Areca nut extracts could account for the decrease in [1,2(n)-H-3]cholesteryl oleate absorption that resulted in decreased radioactivity in blood. Copyright (C) 2000 S. Karger AG, Basel
URI
https://scholarworks.unist.ac.kr/handle/201301/16480
URL
http://www.karger.com/Article/Abstract/12841
DOI
10.1159/000012841
ISSN
0250-6807
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BIO_Journal Papers
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