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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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The mechanism of phospholipase C-gamma 1 regulation

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Title
The mechanism of phospholipase C-gamma 1 regulation
Author
Kim, Myung JongKim, EuikyungRyu, Sung HoSuh, Pann-Ghill
Issue Date
2000-09
Publisher
KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY
Citation
EXPERIMENTAL AND MOLECULAR MEDICINE, v.32, no.3, pp.101 - 109
Abstract
Phospholipase C (PLC)(1) hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-gamma 1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. In this review, we will focus on the activation mechanism and regulatory function of PLC-gamma 1
URI
https://scholarworks.unist.ac.kr/handle/201301/16478
URL
http://www.nature.com/emm/journal/v32/n3/abs/emm200018a.html
DOI
10.1038/emm.2000.18
ISSN
1226-3613
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BIO_Journal Papers
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