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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Overexpression of phospholipase D1 in human breast cancer tissues

Cited 107 times inthomson ciCited 112 times inthomson ci
Title
Overexpression of phospholipase D1 in human breast cancer tissues
Author
Noh, Dong-YoungAhn, Soo-JungLee, Ryung-AhPark, In-AeKim, Jae-HoSuh, Pann-GhillRyu, Sung HoLee, Kweon-HaengHan, Joon-Soo
Issue Date
2000-12
Publisher
ELSEVIER IRELAND LTD
Citation
CANCER LETTERS, v.161, no.2, pp.207 - 214
Abstract
Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline. PLD is a major enzyme implicated in important cellular processes. such as cell proliferation. We designed this study to investigate the expression of PLD in human breast carcinomas and non-malignant tissues using RT-PCR, Western blot analysis, immunohistochemistry and an Arf-dependent PLD activity assay. We examined about 550 bp of PCR product and 120 kDa of PLD protein, Our results showed that PLD protein and mRNA levels were overexpressed in 14 of 17 breast cancer tissues, We also observed increased expression by immunohistochemistry and Arf-dependent PLD activity in microsomes of human breast tumors, which correlated well with PLD expression. PLD expression was elevated in human breast tumors compared with normal breast tissues. These results implicate a possible role of PLD in human breast tumorigenesis and suggest that PLD may be useful as a marker for malignant disease in the breast. (C) 2000 Elsevier Science Ireland Ltd, All rights reserved
URI
https://scholarworks.unist.ac.kr/handle/201301/16477
URL
http://www.sciencedirect.com/science/article/pii/S0304383500006121
DOI
10.1016/S0304-3835(00)00612-1
ISSN
0304-3835
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BIO_Journal Papers
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