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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C


Overexpression of phospholipase D1 in human breast cancer tissues

DC Field Value Language Noh, Dong-Young ko Ahn, Soo-Jung ko Lee, Ryung-Ah ko Park, In-Ae ko Kim, Jae-Ho ko Suh, Pann-Ghill ko Ryu, Sung Ho ko Lee, Kweon-Haeng ko Han, Joon-Soo ko 2015-09-01T08:02:38Z - 2015-08-19 ko 2000-12 ko
dc.identifier.citation CANCER LETTERS, v.161, no.2, pp.207 - 214 ko
dc.identifier.issn 0304-3835 ko
dc.identifier.uri -
dc.description.abstract Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline. PLD is a major enzyme implicated in important cellular processes. such as cell proliferation. We designed this study to investigate the expression of PLD in human breast carcinomas and non-malignant tissues using RT-PCR, Western blot analysis, immunohistochemistry and an Arf-dependent PLD activity assay. We examined about 550 bp of PCR product and 120 kDa of PLD protein, Our results showed that PLD protein and mRNA levels were overexpressed in 14 of 17 breast cancer tissues, We also observed increased expression by immunohistochemistry and Arf-dependent PLD activity in microsomes of human breast tumors, which correlated well with PLD expression. PLD expression was elevated in human breast tumors compared with normal breast tissues. These results implicate a possible role of PLD in human breast tumorigenesis and suggest that PLD may be useful as a marker for malignant disease in the breast. (C) 2000 Elsevier Science Ireland Ltd, All rights reserved ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher ELSEVIER IRELAND LTD ko
dc.title Overexpression of phospholipase D1 in human breast cancer tissues ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-0034695165 ko
dc.identifier.wosid 000168440000011 ko
dc.type.rims ART ko
dc.description.wostc 107 *
dc.description.scopustc 112 *
dc.description.scopustc 112 * 2015-12-28 * 2015-11-04 * 2015-11-04 *
dc.identifier.doi 10.1016/S0304-3835(00)00612-1 ko
dc.identifier.url ko
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