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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Luteolin inhibits the nuclear factor-kappa B transcriptional activity in Rat-1 fibroblasts

Cited 45 times inthomson ciCited 47 times inthomson ci
Title
Luteolin inhibits the nuclear factor-kappa B transcriptional activity in Rat-1 fibroblasts
Author
Kim, Sun-HeeShin, Kum-JooKim, DohanKim, Yun-HeeHan, Myoung SookLee, Taehoon GKim, EuikyungRyu, Sung HoSuh, Pann-Ghill
Issue Date
2003-09
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOCHEMICAL PHARMACOLOGY, v.66, no.6, pp.955 - 963
Abstract
Flavonoids are natural polyphenolic compounds that have anti-inflammatory, cytoprotective and anticarcinogenic effects. In this study, we investigated the effects of several flavonoids on nuclear factor-kappa B (NF-kappaB) activation by using luciferase reporter gene assay. Among the flavonoids examined, luteolin showed the most potent inhibition on lipopolysaccharide (LPS)-stimulated NF-kappaB transcriptional activity in Rat-1 fibroblasts. Luteolin did not inhibit either IkappaBalpha. degradation or NF-kappaB nuclear translocation, DNA binding or phosphorylation by LPS. However, luteolin prevented LPS-stimulated interaction between the p65 subunit of NF-kappaB and the transcriptional coactivator CBP. In addition, a specific PKA inhibitor that blocked the phosphorylation of CREB and c-Jun by luteolin partially reversed the inhibitory effect of luteolin on NF-kappaB(.)CBP complex formation and NF-kappaB transcriptional activity by LPS. These data imply that inhibition of NF-kappaB transcriptional activity by luteolin may occur through competition with transcription factors for coactivator that is available in limited amounts. Taken together, this study provides a molecular basis for the understanding of the antiinflammatory effects of luteolin. (C) 2003 Elsevier Inc. All rights reserved
URI
https://scholarworks.unist.ac.kr/handle/201301/16470
URL
http://www.sciencedirect.com/science/article/pii/S0006295203004659
DOI
10.1016/S0006-2952(03)00465-9
ISSN
0006-2952
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