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DC Field | Value | Language |
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dc.citation.endPage | 963 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 955 | - |
dc.citation.title | BIOCHEMICAL PHARMACOLOGY | - |
dc.citation.volume | 66 | - |
dc.contributor.author | Kim, Sun-Hee | - |
dc.contributor.author | Shin, Kum-Joo | - |
dc.contributor.author | Kim, Dohan | - |
dc.contributor.author | Kim, Yun-Hee | - |
dc.contributor.author | Han, Myoung Sook | - |
dc.contributor.author | Lee, Taehoon G | - |
dc.contributor.author | Kim, Euikyung | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T11:09:29Z | - |
dc.date.available | 2023-12-22T11:09:29Z | - |
dc.date.created | 2015-08-19 | - |
dc.date.issued | 2003-09 | - |
dc.description.abstract | Flavonoids are natural polyphenolic compounds that have anti-inflammatory, cytoprotective and anticarcinogenic effects. In this study, we investigated the effects of several flavonoids on nuclear factor-kappa B (NF-kappaB) activation by using luciferase reporter gene assay. Among the flavonoids examined, luteolin showed the most potent inhibition on lipopolysaccharide (LPS)-stimulated NF-kappaB transcriptional activity in Rat-1 fibroblasts. Luteolin did not inhibit either IkappaBalpha. degradation or NF-kappaB nuclear translocation, DNA binding or phosphorylation by LPS. However, luteolin prevented LPS-stimulated interaction between the p65 subunit of NF-kappaB and the transcriptional coactivator CBP. In addition, a specific PKA inhibitor that blocked the phosphorylation of CREB and c-Jun by luteolin partially reversed the inhibitory effect of luteolin on NF-kappaB(.)CBP complex formation and NF-kappaB transcriptional activity by LPS. These data imply that inhibition of NF-kappaB transcriptional activity by luteolin may occur through competition with transcription factors for coactivator that is available in limited amounts. Taken together, this study provides a molecular basis for the understanding of the antiinflammatory effects of luteolin. (C) 2003 Elsevier Inc. All rights reserved | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL PHARMACOLOGY, v.66, no.6, pp.955 - 963 | - |
dc.identifier.doi | 10.1016/S0006-2952(03)00465-9 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.scopusid | 2-s2.0-0042762838 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/16470 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006295203004659 | - |
dc.identifier.wosid | 000185501200009 | - |
dc.language | 영어 | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Luteolin inhibits the nuclear factor-kappa B transcriptional activity in Rat-1 fibroblasts | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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