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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Phospholipase C isozymes selectively couple to specific neurotransmitter receptors

Cited 190 times inthomson ciCited 195 times inthomson ci
Title
Phospholipase C isozymes selectively couple to specific neurotransmitter receptors
Author
Kim, DaesooJun, Ki SunLee, Seong BeomKang, Nae-GyuMin, Do SikKim, Young-HoonRyu, Sung HoSuh, Pann-GhillShin, Hee-Sup
Issue Date
1997-09
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE, v.389, no.6648, pp.290 - 293
Abstract
A variety of extracellular signals are transduced across the cell membrane by the enzyme phosphoinositide-specific phospholipase C-beta (PLC-beta) coupled with guanine-nucleotide-binding G proteins'. There are four isoenzymes of PLC-beta, beta 1-beta 4, but their functions in vivo are not known. Here we investigate the role of PLC-beta 1 and PLC-beta 4 in the brain by generating-null mutations in mice: we found that PLC beta 1(-/-) mice developed epilepsy and PLC beta 4(-/-) mice showed ataxia. We determined the molecular basis of these phenotypes and show that PLC-beta 1 is involved in signal transduction in the cerebral cortex and hippocampus by coupling pre-dominantly to the muscarinic acetylcholine receptor, whereas PLC-beta 4 works through the metabotropic glutamate receptor in the cerebellum, illustrating how PLC-beta isoenzymes are used to generate different functions in the brain
URI
https://scholarworks.unist.ac.kr/handle/201301/16458
URL
http://www.nature.com/nature/journal/v389/n6648/full/389290a0.html
ISSN
0028-0836
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BIO_Journal Papers
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