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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 293 | - |
dc.citation.number | 6648 | - |
dc.citation.startPage | 290 | - |
dc.citation.title | NATURE | - |
dc.citation.volume | 389 | - |
dc.contributor.author | Kim, Daesoo | - |
dc.contributor.author | Jun, Ki Sun | - |
dc.contributor.author | Lee, Seong Beom | - |
dc.contributor.author | Kang, Nae-Gyu | - |
dc.contributor.author | Min, Do Sik | - |
dc.contributor.author | Kim, Young-Hoon | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Shin, Hee-Sup | - |
dc.date.accessioned | 2023-12-22T12:37:02Z | - |
dc.date.available | 2023-12-22T12:37:02Z | - |
dc.date.created | 2015-08-20 | - |
dc.date.issued | 1997-09 | - |
dc.description.abstract | A variety of extracellular signals are transduced across the cell membrane by the enzyme phosphoinositide-specific phospholipase C-beta (PLC-beta) coupled with guanine-nucleotide-binding G proteins'. There are four isoenzymes of PLC-beta, beta 1-beta 4, but their functions in vivo are not known. Here we investigate the role of PLC-beta 1 and PLC-beta 4 in the brain by generating-null mutations in mice: we found that PLC beta 1(-/-) mice developed epilepsy and PLC beta 4(-/-) mice showed ataxia. We determined the molecular basis of these phenotypes and show that PLC-beta 1 is involved in signal transduction in the cerebral cortex and hippocampus by coupling pre-dominantly to the muscarinic acetylcholine receptor, whereas PLC-beta 4 works through the metabotropic glutamate receptor in the cerebellum, illustrating how PLC-beta isoenzymes are used to generate different functions in the brain | - |
dc.identifier.bibliographicCitation | NATURE, v.389, no.6648, pp.290 - 293 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.scopusid | 2-s2.0-1842373861 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/16458 | - |
dc.identifier.url | http://www.nature.com/nature/journal/v389/n6648/full/389290a0.html | - |
dc.identifier.wosid | A1997XW77200049 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Phospholipase C isozymes selectively couple to specific neurotransmitter receptors | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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