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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Breakthroughs and views - The roles of PDZ-containing proteins in PLC-beta-mediated signaling

Cited 60 times inthomson ciCited 64 times inthomson ci
Title
Breakthroughs and views - The roles of PDZ-containing proteins in PLC-beta-mediated signaling
Author
Suh, Pann-GhillHwang, Jong-IkRyu, Sung HoDonowitz, MarkKim, Jae Ho
Issue Date
2001-10
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.288, no.1, pp.1 - 7
Abstract
Mammalian phospholipase C-beta isozymes are activated by a heterotrimeric GTP-binding protein linked to various cell surface receptors. Recent reports suggest that PDZ domain proteins play a significant role of PDZ-containing proteins in the regulation of mammalian PLC-beta isozymes. PDZ-containing proteins mediate the clustering of receptors and signaling molecules and thereby regulate agonist-induced signal transduction in polarized cells such as neuronal and epithelial cells. NORPA, a Drosophila PLC-beta, is known to be a component of a signaling complex that includes TRP and rhodopsin through interaction with DIAD, a PDZ-containing protein. Mammalian PLC-beta1 and -beta2 isoforms interact with a PDZ-containing protein NHERF which is coupled to Trp4, a Ca2+ channel. In addition, PLC-beta3 specifically interacts with E3KARP, another protein closely related to NHERF, through its C-terminal PDZ-binding motif. E3KARP up-regulates the PLC-beta3 activation coupled to muscarinic receptor. In this review, the role of signaling complexes mediated by PDZ-containing proteins in the regulation of PLC-beta isoforms will be discussed. (C) 2001 Academic Press
URI
https://scholarworks.unist.ac.kr/handle/201301/16450
URL
http://www.sciencedirect.com/science/article/pii/S0006291X01957109
DOI
10.1006/bbrc.2001.5710
ISSN
0006-291X
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