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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 288 | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Hwang, Jong-Ik | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Donowitz, Mark | - |
dc.contributor.author | Kim, Jae Ho | - |
dc.date.accessioned | 2023-12-22T11:41:59Z | - |
dc.date.available | 2023-12-22T11:41:59Z | - |
dc.date.created | 2015-08-20 | - |
dc.date.issued | 2001-10 | - |
dc.description.abstract | Mammalian phospholipase C-beta isozymes are activated by a heterotrimeric GTP-binding protein linked to various cell surface receptors. Recent reports suggest that PDZ domain proteins play a significant role of PDZ-containing proteins in the regulation of mammalian PLC-beta isozymes. PDZ-containing proteins mediate the clustering of receptors and signaling molecules and thereby regulate agonist-induced signal transduction in polarized cells such as neuronal and epithelial cells. NORPA, a Drosophila PLC-beta, is known to be a component of a signaling complex that includes TRP and rhodopsin through interaction with DIAD, a PDZ-containing protein. Mammalian PLC-beta1 and -beta2 isoforms interact with a PDZ-containing protein NHERF which is coupled to Trp4, a Ca2+ channel. In addition, PLC-beta3 specifically interacts with E3KARP, another protein closely related to NHERF, through its C-terminal PDZ-binding motif. E3KARP up-regulates the PLC-beta3 activation coupled to muscarinic receptor. In this review, the role of signaling complexes mediated by PDZ-containing proteins in the regulation of PLC-beta isoforms will be discussed. (C) 2001 Academic Press | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.288, no.1, pp.1 - 7 | - |
dc.identifier.doi | 10.1006/bbrc.2001.5710 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.scopusid | 2-s2.0-0035913998 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/16450 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X01957109 | - |
dc.identifier.wosid | 000171813400001 | - |
dc.language | 영어 | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Breakthroughs and views - The roles of PDZ-containing proteins in PLC-beta-mediated signaling | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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