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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Thiram and ziram stimulate non-selective cation channel and induce apoptosis in PC12 cells

Cited 13 times inthomson ciCited 18 times inthomson ci
Title
Thiram and ziram stimulate non-selective cation channel and induce apoptosis in PC12 cells
Author
Han, Myoung SookShin, Kum-JooKim, Yun-HeeKim, Sun-HeeLee, TaehoonKim, EuikyungRyu, Sung HoSuh, Pann-Ghill
Issue Date
2003-06
Publisher
ELSEVIER SCIENCE BV
Citation
NEUROTOXICOLOGY, v.24, no.3, pp.425 - 434
Abstract
The neurotoxicity of dithiocarbamates has been previously reported, however the detailed mechanism underlying the neurotoxicity is still not fully understood Among the dithiocarbamates, we investigated thiram and ziram in a neuronal-like pheochromocytoma (PC12) cells. Thiram and ziram strongly induced cell death in both dose- and time-dependent manners with the LC50 of 0.3 and 2 muM, respectively. The cell death showed typical apoptotic features, such as DNA fragmentation and an increase of subdiploidy nuclei. Interestingly, both thiram and ziram induced rapid and sustained increases of intracellular Ca2+ in PC12 cells, which were almost completely blocked by flufenamic acid (FFA), an inhibitor of non-selective cation channel. BAPTA-AM, an intracellular Ca2+ chelator inhibited the thiram- and ziraminduced apoptotic cell death. These results suggest that thiram and ziram induce apoptotic neuronal cell death by Ca2+ influx through non-selective cation channels. The present study may provide a clue for understanding the mechanism of neurotoxicity of thiram and ziram. (C) 2003 Published by Elsevier Science Inc
URI
https://scholarworks.unist.ac.kr/handle/201301/16432
URL
http://www.sciencedirect.com/science/article/pii/S0161813X03000135
DOI
10.1016/S0161-813X(03)00013-5
ISSN
0161-813X
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