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DC Field | Value | Language |
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dc.citation.endPage | 434 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 425 | - |
dc.citation.title | NEUROTOXICOLOGY | - |
dc.citation.volume | 24 | - |
dc.contributor.author | Han, Myoung Sook | - |
dc.contributor.author | Shin, Kum-Joo | - |
dc.contributor.author | Kim, Yun-Hee | - |
dc.contributor.author | Kim, Sun-Hee | - |
dc.contributor.author | Lee, Taehoon | - |
dc.contributor.author | Kim, Euikyung | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T11:11:23Z | - |
dc.date.available | 2023-12-22T11:11:23Z | - |
dc.date.created | 2015-08-21 | - |
dc.date.issued | 2003-06 | - |
dc.description.abstract | The neurotoxicity of dithiocarbamates has been previously reported, however the detailed mechanism underlying the neurotoxicity is still not fully understood Among the dithiocarbamates, we investigated thiram and ziram in a neuronal-like pheochromocytoma (PC12) cells. Thiram and ziram strongly induced cell death in both dose- and time-dependent manners with the LC50 of 0.3 and 2 muM, respectively. The cell death showed typical apoptotic features, such as DNA fragmentation and an increase of subdiploidy nuclei. Interestingly, both thiram and ziram induced rapid and sustained increases of intracellular Ca2+ in PC12 cells, which were almost completely blocked by flufenamic acid (FFA), an inhibitor of non-selective cation channel. BAPTA-AM, an intracellular Ca2+ chelator inhibited the thiram- and ziraminduced apoptotic cell death. These results suggest that thiram and ziram induce apoptotic neuronal cell death by Ca2+ influx through non-selective cation channels. The present study may provide a clue for understanding the mechanism of neurotoxicity of thiram and ziram. (C) 2003 Published by Elsevier Science Inc | - |
dc.identifier.bibliographicCitation | NEUROTOXICOLOGY, v.24, no.3, pp.425 - 434 | - |
dc.identifier.doi | 10.1016/S0161-813X(03)00013-5 | - |
dc.identifier.issn | 0161-813X | - |
dc.identifier.scopusid | 2-s2.0-0038348746 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/16432 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0161813X03000135 | - |
dc.identifier.wosid | 000183587100010 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Thiram and ziram stimulate non-selective cation channel and induce apoptosis in PC12 cells | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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