BROWSE

Related Researcher

Author's Photo

Bhak, Jong
KOrean GenomIcs Center(KOGIC)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS

ITEM VIEW & DOWNLOAD

Estimating the significance of sequence order in protein secondary structure and prediction

Cited 6 times inthomson ciCited 6 times inthomson ci
Title
Estimating the significance of sequence order in protein secondary structure and prediction
Other Titles
Estimating the significance of sequence order in protein secondary structure and prediction.
Author
Bhak, Jong HwaDietmann, SabineHeger, AndreasHolm, Liisa
Keywords
FOLD RECOGNITION; GLOBULAR-PROTEINS; ALIGNMENT; IDENTIFICATION; DATABASE; ACCURACY; IMPROVEMENTS; PERFORMANCE; PARAMETERS; HOMOLOGY
Issue Date
2000-11
Publisher
OXFORD UNIV PRESS
Citation
BIOINFORMATICS, v.16, no.11, pp.978 - 987
Abstract
Motivation: How critical is the sequence order information in predicting protein secondary structure segments? We tried to get a rough insight on it from a theoretical approach using both a prediction algorithm and structural fragments from Protein Databank (PDB). Results: Using reverse protein sequences and PDB structural fragments, we theoretically estimated the significance of the order for protein secondary structure and prediction. On average: (1) 79% of protein sequence segments resulted in the same prediction in both normal and reverse directions, which indicated a relatively high conservation of secondary structure propensity in the reverse direction; (2) the reversed sequence prediction alone performed less accurately than the normal forward sequence prediction, but comparably high (2% difference); (3) the commonly predicted regions showed a slightly higher prediction accuracy (4%) than the normal sequences prediction; and (4) structural fragments which have counterparts in reverse direction in the same protein showed a comparable degree of secondary structure conservation (73% identity with reversed structures on average for pentamers)
URI
Go to Link
DOI
10.1093/bioinformatics/16.11.978
ISSN
1367-4803
Appears in Collections:
BME_Journal Papers
Files in This Item:
Bioinformatics-2000-Park-978-87 (1).pdf Download

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU