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Bhak, Jong
KOrean GenomIcs Center(KOGIC)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS

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Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear

Cited 11 times inthomson ciCited 5 times inthomson ci
Title
Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear
Other Titles
Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear
Author
Jovine, LucaBhak, Jong HwaWassarman, Paul M
Keywords
NON-SYNDROMIC DEAFNESS; TECTORIAL MEMBRANE; MUTATIONS; PROTEIN; MESOTHELIN
Issue Date
2002-11
Publisher
BIOMED CENTRAL LTD
Citation
BMC CELL BIOLOGY, v.3, no.1, pp.28 -
Abstract
Background: Interaction between hair cells and acellular gels of the mammalian inner ear, the tectorial and otoconial membranes, is crucial for mechanoreception. Recently, otoancorin was suggested to be a mediator of gel attachment to nonsensory cells, but the molecular components of the interface between gels and sensory cells remain to be identified. Hypothesis: We report that the inner ear protein stereocilin is related in sequence to otoancorin and, based on its localisation and predicted GPI-anchoring, may mediate attachment of the tectorial and otoconial membranes to sensory hair bundles. Testing: It is expected that antibodies directed against stereocilin would specifically label sites of contact between sensory hair cells and tectorial/otoconial membranes of the inner ear. Implications: Our findings support a unified molecular mechanism for mechanotransduction, with stereocilin and otoancorin defining a new protein family responsible for the attachment of acellular gels to both sensory and nonsensory cells of the inner ear
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DOI
10.1186/1471-2121-3-28
ISSN
1471-2121
Appears in Collections:
BME_Journal Papers
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