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DC Field | Value | Language |
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dc.citation.number | 1 | - |
dc.citation.startPage | 28 | - |
dc.citation.title | BMC CELL BIOLOGY | - |
dc.citation.volume | 3 | - |
dc.contributor.author | Jovine, Luca | - |
dc.contributor.author | Bhak, Jong Hwa | - |
dc.contributor.author | Wassarman, Paul M | - |
dc.date.accessioned | 2023-12-22T11:36:34Z | - |
dc.date.available | 2023-12-22T11:36:34Z | - |
dc.date.created | 2015-08-03 | - |
dc.date.issued | 2002-11 | - |
dc.description.abstract | Background: Interaction between hair cells and acellular gels of the mammalian inner ear, the tectorial and otoconial membranes, is crucial for mechanoreception. Recently, otoancorin was suggested to be a mediator of gel attachment to nonsensory cells, but the molecular components of the interface between gels and sensory cells remain to be identified. Hypothesis: We report that the inner ear protein stereocilin is related in sequence to otoancorin and, based on its localisation and predicted GPI-anchoring, may mediate attachment of the tectorial and otoconial membranes to sensory hair bundles. Testing: It is expected that antibodies directed against stereocilin would specifically label sites of contact between sensory hair cells and tectorial/otoconial membranes of the inner ear. Implications: Our findings support a unified molecular mechanism for mechanotransduction, with stereocilin and otoancorin defining a new protein family responsible for the attachment of acellular gels to both sensory and nonsensory cells of the inner ear | - |
dc.identifier.bibliographicCitation | BMC CELL BIOLOGY, v.3, no.1, pp.28 | - |
dc.identifier.doi | 10.1186/1471-2121-3-28 | - |
dc.identifier.issn | 1471-2121 | - |
dc.identifier.scopusid | 2-s2.0-0037176127 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/13246 | - |
dc.identifier.url | http://www.biomedcentral.com/1471-2121/3/28 | - |
dc.identifier.wosid | 000179958900001 | - |
dc.language | 영어 | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.title.alternative | Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear | - |
dc.title | Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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