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An, Kwangjin
Advanced Nanocatalysis Lab (An Lab)
Research Interests
  • Nanoparticle catalytsts, catalytic activity, selectivity, and stability, strong metal-support interactions, biofuel conversion

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In vitro cytotoxicity screening of water-dispersible metal oxide nanoparticles in human cell lines

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Title
In vitro cytotoxicity screening of water-dispersible metal oxide nanoparticles in human cell lines
Author
Choi, Jong YoungLee, Su HeeNa, Hyon BinAn, KwangjinHyeon, TaeghwanSeo, Tae Seok
Keywords
Cytotoxicity; Magnetic resonance imaging contrast agents; Nanotoxicology; Water-dispersible Fe3O4 and MnO nanoparticle
Issue Date
2010-01
Publisher
SPRINGER
Citation
BIOPROCESS AND BIOSYSTEMS ENGINEERING, v.33, no.1, pp.21 - 30
Abstract
In this study, we present in vitro cytotoxicity of iron oxide (Fe 3O4) and manganese oxide (MnO) using live/dead cell assay, lactate dehydrogenase assay, and reactive oxygen species detection with variation of the concentration of nanoparticles (5-500 μg/ml), incubation time (18-96 h), and different human cell lines (lung adenocarcinoma, breast cancer cells, and glioblastoma cells). The surface of nanoparticles is modified with polyethyleneglycol-derivatized phospholipid to enhance the biocompatibility, water-solubility, and stability under an aqueous media. While the cytotoxic effect was negligible for 18 h incubation even at highest concentration of 500 μg/ml, MnO nanoparticle represented higher level of toxicity than those of Fe3O4 and the commercial medical contrast reagent, Feridex after 2 and 4 day incubation time. However, the cytotoxicity of Fe3O4 is equivalent or better than Feridex based on the live/dead cell viability assay. The engineered MnO and Fe 3O4 exhibited excellent stability compared with Feridex for a prolonged incubation time. © 2009 Springer-Verlag.
URI
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DOI
10.1007/s00449-009-0354-5
ISSN
1615-7591
Appears in Collections:
ECHE_Journal Papers
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