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An, Kwangjin
Advanced Nanocatalysis Lab (An Lab)
Research Interests
  • Nanoparticle catalytsts, catalytic activity, selectivity, and stability, strong metal-support interactions, biofuel conversion

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In vitro cytotoxicity screening of water-dispersible metal oxide nanoparticles in human cell lines

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dc.contributor.author Choi, Jong Young ko
dc.contributor.author Lee, Su Hee ko
dc.contributor.author Na, Hyon Bin ko
dc.contributor.author An, Kwangjin ko
dc.contributor.author Hyeon, Taeghwan ko
dc.contributor.author Seo, Tae Seok ko
dc.date.available 2015-07-29T00:55:46Z -
dc.date.created 2015-07-28 ko
dc.date.issued 2010-01 -
dc.identifier.citation BIOPROCESS AND BIOSYSTEMS ENGINEERING, v.33, no.1, pp.21 - 30 ko
dc.identifier.issn 1615-7591 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/12858 -
dc.identifier.uri http://link.springer.com/article/10.1007%2Fs00449-009-0354-5 ko
dc.description.abstract In this study, we present in vitro cytotoxicity of iron oxide (Fe 3O4) and manganese oxide (MnO) using live/dead cell assay, lactate dehydrogenase assay, and reactive oxygen species detection with variation of the concentration of nanoparticles (5-500 μg/ml), incubation time (18-96 h), and different human cell lines (lung adenocarcinoma, breast cancer cells, and glioblastoma cells). The surface of nanoparticles is modified with polyethyleneglycol-derivatized phospholipid to enhance the biocompatibility, water-solubility, and stability under an aqueous media. While the cytotoxic effect was negligible for 18 h incubation even at highest concentration of 500 μg/ml, MnO nanoparticle represented higher level of toxicity than those of Fe3O4 and the commercial medical contrast reagent, Feridex after 2 and 4 day incubation time. However, the cytotoxicity of Fe3O4 is equivalent or better than Feridex based on the live/dead cell viability assay. The engineered MnO and Fe 3O4 exhibited excellent stability compared with Feridex for a prolonged incubation time. © 2009 Springer-Verlag. ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher SPRINGER ko
dc.subject Cytotoxicity ko
dc.subject Magnetic resonance imaging contrast agents ko
dc.subject Nanotoxicology ko
dc.subject Water-dispersible Fe3O4 and MnO nanoparticle ko
dc.title In vitro cytotoxicity screening of water-dispersible metal oxide nanoparticles in human cell lines ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-76849101781 ko
dc.identifier.wosid 000272910600003 ko
dc.type.rims ART ko
dc.description.wostc 38 *
dc.description.scopustc 39 *
dc.date.tcdate 2015-12-28 *
dc.date.scptcdate 2015-11-04 *
dc.identifier.doi 10.1007/s00449-009-0354-5 ko
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