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An, Kwangjin
Advanced Nanocatalysis Lab (An Lab)
Research Interests
  • Nanoparticle catalytsts, catalytic activity, selectivity, and stability, strong metal-support interactions, biofuel conversion


In vitro cytotoxicity screening of water-dispersible metal oxide nanoparticles in human cell lines

DC Field Value Language Choi, Jong Young ko Lee, Su Hee ko Na, Hyon Bin ko An, Kwangjin ko Hyeon, Taeghwan ko Seo, Tae Seok ko 2015-07-29T00:55:46Z - 2015-07-28 ko 2010-01 -
dc.identifier.citation BIOPROCESS AND BIOSYSTEMS ENGINEERING, v.33, no.1, pp.21 - 30 ko
dc.identifier.issn 1615-7591 ko
dc.identifier.uri -
dc.identifier.uri ko
dc.description.abstract In this study, we present in vitro cytotoxicity of iron oxide (Fe 3O4) and manganese oxide (MnO) using live/dead cell assay, lactate dehydrogenase assay, and reactive oxygen species detection with variation of the concentration of nanoparticles (5-500 μg/ml), incubation time (18-96 h), and different human cell lines (lung adenocarcinoma, breast cancer cells, and glioblastoma cells). The surface of nanoparticles is modified with polyethyleneglycol-derivatized phospholipid to enhance the biocompatibility, water-solubility, and stability under an aqueous media. While the cytotoxic effect was negligible for 18 h incubation even at highest concentration of 500 μg/ml, MnO nanoparticle represented higher level of toxicity than those of Fe3O4 and the commercial medical contrast reagent, Feridex after 2 and 4 day incubation time. However, the cytotoxicity of Fe3O4 is equivalent or better than Feridex based on the live/dead cell viability assay. The engineered MnO and Fe 3O4 exhibited excellent stability compared with Feridex for a prolonged incubation time. © 2009 Springer-Verlag. ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher SPRINGER ko
dc.subject Cytotoxicity ko
dc.subject Magnetic resonance imaging contrast agents ko
dc.subject Nanotoxicology ko
dc.subject Water-dispersible Fe3O4 and MnO nanoparticle ko
dc.title In vitro cytotoxicity screening of water-dispersible metal oxide nanoparticles in human cell lines ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-76849101781 ko
dc.identifier.wosid 000272910600003 ko
dc.type.rims ART ko
dc.description.wostc 38 *
dc.description.scopustc 39 * 2015-12-28 * 2015-11-04 *
dc.identifier.doi 10.1007/s00449-009-0354-5 ko
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