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Ko, Myunggon
Molecular Immunology & Cancer Epigenetics
Research Interests
  • TET proteins, DNA hydroxymethylation, oncogenesis, cancer stem cells, cancer therapy

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Srg3 is a novel p53 target and acts as a tumor suppressor by modulating p21WAF1/CIP1 expression

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Title
Srg3 is a novel p53 target and acts as a tumor suppressor by modulating p21WAF1/CIP1 expression
Author
Ahn, JungeunKo, Myung GonLee, ChangjinKim, JieunYoon, HanaSeong, Rho H
Issue Date
2011-01
Publisher
NATURE PUBLISHING GROUP
Citation
ONCOGENE, v.30, no.4, pp.445 - 456
Abstract
Some subunits of the SWI/SNF complex function as tumor suppressors. However, underlying mechanisms are still incompletely defined. Here, we show that Srg3, a mouse homolog of BAF155 that function as a core subunit of this complex, suppresses tumorigenesis in vivo. DNA damage signals promoted Srg3 degradation by inducing p53. Deficiency of Srg3 promoted G1 cell-cycle arrest, but antagonized apoptotic response to DNA damage by robustly inducing p53 and p21 proteins. Srg3 heterozygous mice were prone to sarcoma formation, which was further enhanced by haploinsufficiency of p53. These tumors highly expressed p53 and p21 but lacked Srg3 expression. Our results establish a novel function of Srg3 in tumor suppression and provide insights into genetic pathways dictating tumor suppression by the SWI/SNF complex.
URI
https://scholarworks.unist.ac.kr/handle/201301/12636
DOI
10.1038/onc.2010.424
ISSN
0950-9232
Appears in Collections:
PHY_Journal Papers
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