Label-free CMOS Bio Sensor with On-chip Noise Reduction Scheme for Real-time Quantitative Monitoring of Biomolecules
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- Label-free CMOS Bio Sensor with On-chip Noise Reduction Scheme for Real-time Quantitative Monitoring of Biomolecules
- Kim, Seong-Jin; Yoon, Euisik
- Issue Date
- IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
- IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, v.6, no.3, pp.189 - 196
- We present a label-free CMOS field-effect transistor sensing array to detect the surface potential change affected by the negative charge in DNA molecules for real-time monitoring and quantification. The proposed CMOS bio sensor includes a new sensing pixel architecture implemented with correlated double sampling for reducing offset fixed pattern noise and 1/f noise of the sensing devices. We incorporated non-surface binding detection which allows real-time continuous monitoring of DNA concentrations without immobilizing them on the sensing surface. Various concentrations of 19-bp oligonucleotides solution can be discriminated using the prototype device fabricated in 1-μm double-poly double-metal standard CMOS process. The detection limit was measured as 1.1 ng/μl with a dynamic range of 40 dB and the transient response time was measured less than 20 seconds. © 2011 IEEE.
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