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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Identification of a new functional target of haloperidol metabolite: implications for a receptor-independent role of 3-(4-fluorobenzoyl) propionic acid

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Title
Identification of a new functional target of haloperidol metabolite: implications for a receptor-independent role of 3-(4-fluorobenzoyl) propionic acid
Author
Kim, Hyeon SooSong, MinseokYumkham, SanatombiChoi, Jang HyunLee, TaehoonKwon, JosephLee, Sung JaeKim, Jong-InLee, Kang-WooHan, Pyung-LimShin, Seung WooBaik, Ja-HyunKim, Yong SikRyu, Sung HoSuh, Pann-Ghill
Issue Date
2006-10
Publisher
WILEY-BLACKWELL
Citation
JOURNAL OF NEUROCHEMISTRY, v.99, no.2, pp.458 - 469
Abstract
Haloperidol, a dopamine D2 receptor blocker, is a classical neuroleptic drug that elicits extrapyramidal symptoms. Its metabolites include 3-(4-fluorobenzoyl) propionic acid (FBPA) and 4-(4-chlorophenyl)-4-piperidinol (CPHP). Until now, the biological significance of these metabolites has remained largely unknown. Here, we report that the administration of FBPA to mice effected a suppression of locomotor activity and induced catalepsy in a manner similar to that observed with haloperidol, whereas CPHP had no significant effects. Neither of these two metabolites, however, exhibited any ability to bind to the dopamine D2 receptor. FBPA blocked dopamine-induced extracellular signal-regulated kinase 1/2 phosphorylation, and it specifically affected mitogen-activated protein kinase kinase (MEK)1/2 activity in hippocampal HN33 cells. Moreover, FBPA was capable of direct interaction with MEK1/2, and inhibited its activity in vitro. We demonstrated the generation of haloperidol metabolites within haloperidol-treated cells by mass spectrometric analyses. Collectively, our results confirm the biological activity of FBPA, and provide initial clues as to the receptor-independent role of haloperidol.
URI
https://scholarworks.unist.ac.kr/handle/201301/11001
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33749173664
DOI
10.1111/j.1471-4159.2006.04108.x
ISSN
0022-3042
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BIO_Journal Papers
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