BROWSE

Related Researcher

Author's Photo

Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

ITEM VIEW & DOWNLOAD

Epidermal growth factor increases insulin secretion and lowers blood glucose in diabetic mice

Cited 13 times inthomson ciCited 12 times inthomson ci
Title
Epidermal growth factor increases insulin secretion and lowers blood glucose in diabetic mice
Author
Lee, H. Y.Yea, K.Kim, J.Lee, B. D.Chae, Young ChanKim, H. S.Lee, D. -W.Kim, S. -H.Cho, J. -H.Jin, C. J.Koh, D. -S.Park, K. S.Suh, Pann-GhillRyu, S. H.
Issue Date
2008-09
Publisher
WILEY-BLACKWELL
Citation
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v.12, no.5A, pp.1593 - 1604
Abstract
Epidermal growth factor (EGF) is synthesized in the pancreas and diabetic animals have low levels of EGF. However, the role of EGF in regulating the major function of the pancreas, insulin secretion, has not been studied. Here, we show that EGF rapidly increased insulin secretion in mouse pancreatic islets, as well as in a pancreatic beta-cell line. These events were dependent on a Ca2+ influx and phospholipase D (PLD) activity, particularly PLD2, as determined using pharmacological blockers and molecular manipulations such as over-expression and siRNA of PLD isozymes. In addition, EGF also increased plasma insulin levels and mediated glucose lowering in normal and diabetic mice. Here, for the first time, we provide evidence that EGF is a novel secretagogue that regulates plasma glucose levels and a candidate for the development of therapeutics for diabetes.
URI
https://scholarworks.unist.ac.kr/handle/201301/10825
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=54049132474
DOI
10.1111/j.1582-4934.2007.00169.x
ISSN
1582-1838
Appears in Collections:
BIO_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU