File Download
There are no files associated with this item.
SFX Link
- Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
- Kee, Jung-Min
- Bioorganic and Chembio Lab.
Views & Downloads
Detailed Information
Cited time in 
Cited time in 
Cited time in
Metadata Downloads
Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors
- Author(s)
- Wender, Paul A., Axtman, Alison D., Golden, Jennifer E., Kee, Jung-Min, Sirois, Lauren E., Quiroz, Ryan V., Stevens, Matthew C.
- Issued Date
- 2014-12
- Citation
- ORGANIC CHEMISTRY FRONTIERS, v.1, no.10, pp.1166 - 1171
- Abstract
- The human kinome comprises over 500 protein kinases. When mutated or over-expressed, many play critical roles in abnormal cellular functions associated with cancer, cardiovascular disease and neurological disorders. Here we report a step-economical approach to designed kinase inhibitors inspired by the potent, but non-selective, natural product staurosporine, and synthetically enabled by a novel, complexity-increasing, serialized [5 + 2]/[4 + 2] cycloaddition strategy. This function-oriented synthesis approach rapidly affords tunable scaffolds, and produced a low nanomolar inhibitor of protein kinase C.
- Publisher
- Royal Society of Chemistry
- ISSN
- 2052-4129
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.