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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1171 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1166 | - |
dc.citation.title | ORGANIC CHEMISTRY FRONTIERS | - |
dc.citation.volume | 1 | - |
dc.contributor.author | Wender, Paul A. | - |
dc.contributor.author | Axtman, Alison D. | - |
dc.contributor.author | Golden, Jennifer E. | - |
dc.contributor.author | Kee, Jung-Min | - |
dc.contributor.author | Sirois, Lauren E. | - |
dc.contributor.author | Quiroz, Ryan V. | - |
dc.contributor.author | Stevens, Matthew C. | - |
dc.date.accessioned | 2023-12-22T01:48:02Z | - |
dc.date.available | 2023-12-22T01:48:02Z | - |
dc.date.created | 2015-02-05 | - |
dc.date.issued | 2014-12 | - |
dc.description.abstract | The human kinome comprises over 500 protein kinases. When mutated or over-expressed, many play critical roles in abnormal cellular functions associated with cancer, cardiovascular disease and neurological disorders. Here we report a step-economical approach to designed kinase inhibitors inspired by the potent, but non-selective, natural product staurosporine, and synthetically enabled by a novel, complexity-increasing, serialized [5 + 2]/[4 + 2] cycloaddition strategy. This function-oriented synthesis approach rapidly affords tunable scaffolds, and produced a low nanomolar inhibitor of protein kinase C. | - |
dc.identifier.bibliographicCitation | ORGANIC CHEMISTRY FRONTIERS, v.1, no.10, pp.1166 - 1171 | - |
dc.identifier.doi | 10.1039/c4qo00228h | - |
dc.identifier.issn | 2052-4129 | - |
dc.identifier.scopusid | 2-s2.0-84925450037 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/10810 | - |
dc.identifier.url | http://pubs.rsc.org/en/Content/ArticleLanding/2014/QO/C4QO00228H#!divAbstract | - |
dc.identifier.wosid | 000364430800005 | - |
dc.language | 영어 | - |
dc.publisher | Royal Society of Chemistry | - |
dc.title | Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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