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Kee, Jung-Min
Bioorganic and Chembio Lab
Research Interests
  • Chemical biology, organic synthesis, peptide chemistry, synthetic protein chemistry

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A second-generation phosphohistidine analog for production of phosphohistidine antibodies

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Title
A second-generation phosphohistidine analog for production of phosphohistidine antibodies
Author
Kee, Jung-MinOslund, Rob C.Couvillon, Anthony D.Muir, Tom W.
Issue Date
2015-01
Publisher
AMER CHEMICAL SOC
Citation
ORGANIC LETTERS, v.17, no.2, pp.187 - 189
Abstract
Protein histidine phosphorylation plays a crucial role in cell signaling and central metabolism. However, its detailed functions remain elusive due to technical challenges in detecting and isolating proteins bearing phosphohistidine (pHis), a labile posttranslational modification (PTM). To address this issue, we previously developed the first pHis-specific antibodies using stable, synthetic triazole-based pHis analogs. A second-generation, pyrazole-based pHis analog that enabled the development of a pan-pHis antibody with much improved pHis specificity is now reported.
URI
https://scholarworks.unist.ac.kr/handle/201301/10401
URL
http://pubs.acs.org/doi/abs/10.1021/ol503320p
DOI
10.1021/ol503320p
ISSN
1523-7060
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PHY_Journal Papers
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