A second-generation phosphohistidine analog for production of phosphohistidine antibodies
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- A second-generation phosphohistidine analog for production of phosphohistidine antibodies
- Kee, Jung-Min; Oslund, Rob C.; Couvillon, Anthony D.; Muir, Tom W.
- Issue Date
- AMER CHEMICAL SOC
- ORGANIC LETTERS, v.17, no.2, pp.187 - 189
- Protein histidine phosphorylation plays a crucial role in cell signaling and central metabolism. However, its detailed functions remain elusive due to technical challenges in detecting and isolating proteins bearing phosphohistidine (pHis), a labile posttranslational modification (PTM). To address this issue, we previously developed the first pHis-specific antibodies using stable, synthetic triazole-based pHis analogs. A second-generation, pyrazole-based pHis analog that enabled the development of a pan-pHis antibody with much improved pHis specificity is now reported.
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