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Novel in vivo pan-Hsp90 family inhibitor, panvotinib-401, showed potent anticancer activities without HSF1 activation

Conference Paper Issue Date2016-04-22 View2

Novel in vivo pan-Hsp90 family protein inhibitor, Panvotinib-401, promote anticancer activities by suppressing HSF1 activity

Park, Hey-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2016-11-02 View3

Novel TRAP1 inhibitor targeting the allosteric drug binding site showed improved anti-cancer activity

Hu, Sung , Yoon, Namgu , Kang, Byoung Heon

Conference Paper Issue Date2019-06-19 View4

OGA heterozygosity suppresses intestinal tumorigenesis in Apc min/+ mice File File

Yang, Yongryoul , Jang H.J. , Yoon, Sunyoung , Lee, Yonghwa , Nam, Dougu , Kim, I.S. , Lee, Heeseok , Kim, Hyun , Choi, Jang Hyun , Kang, Byoung Heon , et al

Article Issue Date2014-07 View18

Oncogenic isocitrate dehydrogenase 2 is powerfully targeted by inhibition of a mitochondrial chaperone

허성 , 강병헌

Conference Paper Issue Date2018-11-07 View7

Open and closed conformation TRAP1 crystal structures and development of a purine scaffold mitochondria-targeted Hsp90 inhibitor

Kang, Byoung Heon , None

Conference Paper Issue Date2014-10-16 View4

Overcoming Chemo-resistance through TRAP1 Inhibition Targeting High Mitochondrial Activity in Relapse/Refractory Acute Myeloid Leukemia

Hu, Sung , Park, Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2022-09-29 View7

Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors File

Park, Hye-Kyung , Jeong, Hanbin , Ko, Eunhwa , Lee, Geumwoo , Lee, Ji-Eun , Lee, Sang Kwang , Lee, An-Jung , Im, Jin Young , Hu, Sung , Kim, Seong Heon , et al

Article Issue Date2017-09 View18

Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors

Park, Hye-Kyung , Jeong, Hanbin , Ko, Eunhwa , Lee, Geunwoo , Lee, Ji-Eun , Lee, Sang Kwang , Lee, An-Jung , Lee, Jin Young , Hu, Sung , Kin, Seong Heon , et al

Conference Paper Issue Date2018-06-28 View10

PDZ Domain-containing 1 (PDZK1) Protein Regulates Phospholipase C-beta 3 (PLC-beta 3)-specific Activation of Somatostatin by Forming a Ternary Complex with PLC-beta 3 and Somatostatin Receptors File

Kim, Jung Kuk , Kwon, Ohman , Kim, Jinho , Kim, Eung-Kyun , Park, Hye Kyung , Lee, Ji Eun , Kim, Kyung Lock , Choi, Jung Woong , Lim, Seyoung , Seok, Heon , et al

Article Issue Date2012-06 View8

Possibility of metabolic control mechanism by Tumor necrosis factor receptor-associated protein 1 (TRAP1) regulating pyruvate dehydrogenase (PDH)

Lee, Anjung , Kang, Byoung Heon

Conference Paper Issue Date2017-05-18 View2

Preclinical Characterization of Mitochondria-Targeted Small Molecule Hsp90 Inhibitors, Gamitrinibs, in Advanced Prostate Cancer File

Kang, Byoung Heon , Siegelin, Markus D. , Plescia, Janet , Raskett, Christopher M. , Garlick, David S. , Dohi, Takehiko , Lian, Jane B. , Stein, Gary S. , Languino, Lucia R. , Altieri, Dario C.

Article Issue Date2010-10 View12

Pro-tumorigenic function of cancer-associated adipocytes depends on the mitochondrial chaperone, TRAP1

Yoon, Nam Gu , Kim, So-Yeon , Kong, Sun-Young , Kang, Byoung Heon

Conference Paper Issue Date2023-09-21 View6

Quaternary ammonium-based mitochondria targeting anticancer agents with high water solubility File

Kim, Sangpil , Yoon, Nam Gu , Jana, Batakrishna , Kang, Byoung Heon , Ryu, Ja-Hyoung

Article Issue Date2022-03 View20

Regulation of cell death by mitochondrial chaperone networks in cancer cells

Kang, Byoung Heon

Conference Paper Issue Date2011 View2

Regulation of cell death by mitochondrial Hsp90s

Kang, Byoung Heon

Conference Paper Issue Date2010 View2

Regulation of cellular metabolism by mitochondrial chaperone TRAP1: therapeutic opportunities

Kang, Byoung Heon

Conference Paper Issue Date2019-05-09 View9

Regulation of survivin stability by the aryl hydrocarbon receptor-interacting protein File

Kang, Byoung Heon , Altieri, Dario C.

Article Issue Date2006-08 View10

Regulation of TRAP1 and SIRT3 in glioma stem cells

Park, Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2019-06-19 View4

Regulation of tumor cell mitochondrial Homeostasis by an organelle-specific Hsp90 chaperone network File

Kang, Byoung Heon , Plescia, Janet , Dohi, Takehiko , Rosa, Jack , Doxsey, Stephen J. , Altieri, Dario C.

Article Issue Date2007-10 View6

ROS dependent HIF-1α and CypD negative feedback promotes hypoxia-induced cancer metastasis

Park, Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2021-12-10 View7

ROS dependent HIF-1α/CypD negative feedback promotes hypoxia-induced cancer metastasis.

Park, Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2021-08-25 View7

ROS regulation by Cyclophilin D contributes cancer metastasis via hypoxic signaling

Park, Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2020-10-05 View4

Simultaneous inhibition of Hsp90 family proteins promotes apoptotic cell death via calcineurin activity

Park, Hye-Kyung , Noh, Dong Yeon , Kang, Byoung Heon

Conference Paper Issue Date2017-05-18 View4

SMx inactivates mitochondrial chaperone TRAP1 by interacting with the client binding site

Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2021-08-25 View8

SSBP1 (Single Strand DNA Binding Protein), Binds To TRAP1, A Chaperone Protein In The Mitochondria, To Maintain Mitochondrial Integrity

Lee, Ji Hye , Kang, Byoung Heon

Conference Paper Issue Date2023-11-06 View6

SSBP1, a single-strand DNA binding protein 1, maintains mitochondrial integrity by modulating the mitochondrial chaperone protein TRAP1.

Lee, Ji Hye , Kang, Byoung Heon

Conference Paper Issue Date2023-02-22 View9

Stress signal propagation from mitochondria to ER and development of combination cancer therapeutics

Kang, Byoung Heon

Conference Paper Issue Date2012 View2

Structure, Function, and Inhibitors of the Mitochondrial Chaperone TRAP1 File

Kang, Soo Sung , Kang, Byoung Heon

Article Issue Date2022-12 View18

Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease File

Kang, Byoung Heon , Tavecchio, M. , Goel, H. L. , Hsieh, C. -C , Garlick, D. S. , Raskett, C. M. , Lian, J. B. , Stein, G. S. , Languino, L. R. , Altieri, D. C.

Article Issue Date2011-02 View7

Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy File File

Kim, So‐Yeon , Yoon, Nam Gu , Im, Jin Young , Lee, Ji Hye , Kim, Juhee , Jeon, Yujin , Choi, Young Jae , Lee, Jong‐Hwa , Uemura, Akiyoshi , Park, Dong Ho , et al

Article Issue Date2024-01 View510

Targeting TRAP1 in the tumor microenvironment: inhibitors and breast cancer treatment

Kang, Byoung Heon

Conference Paper Issue Date2023-10-27 View8

Temperature and salt effects on proteolytic function of turnip mosaic potyvirus nuclear inclusion protein a exhibiting a low-temperature optimum activity File

Kim, DH , Kang, Byoung Heon , Han, JS , Choi, KY

Article Issue Date2000-07 View8

The mitochondrial HSP90 TRAP1 regulate hypoxic tumor microenvironment.

Kim, So Yeon , Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2022-02-17 View8

The mitochondrial HSP90, TRAP1 regulates hypoxic environment via stability of HIF1α.

Kim, So Yeon , Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2022-08-26 View8

The novel resveratrol derivative 3,5-diethoxy-3', 4'-dihydroxy-trans-stilbene induces mitochondrial ROS-mediated ER stress and cell death in human hepatoma cells in vitro File

Park, Jae-woo , Choi, Woo-gyun , Lee, Phil-jun , Chung, Su-wol , Kim, Byung-sam , Chung, Hun-taeg , Cho, Sungchan , Kim, Jong-heon , Kang, Byoung Heon , Kim, Hyoungsu , et al

Article Issue Date2017-08 View21

The pro-tumorigenic role of cancer-associated adipocytes relies on the mitochondrial chaperone, TRAP1.

Yoon, Nam Gu , Kim, So-yeon , Kang, Byoung Heon

Conference Paper Issue Date2023-10-28 View5

The role of mitochondrial chaperone TRAP1 in tumorigenesis under hypoxic condition in glioblastoma

김소연 , 강병헌

Conference Paper Issue Date2018-11-07 View7

The Structure of Pro-caspase-6 is Similar to That of Active Mature Caspase-6

Kang, Byoung Heon

Conference Paper Issue Date2001-01-01 View3

THE STRUCTURE OF PRO-CASPASE-6 IS SIMILAR TO THAT OF MATURE FORM

Kang, Byoung Heon

Conference Paper Issue Date2001-01-01 View3

The structure of procaspase 6 is similar to that of active mature caspase 6 File

Kang, Byoung Heon , Ko, E , Kwon, OK , Choi, KY

Article Issue Date2002-06 View5

TonEBP in Myeloid Cells Promotes Obesity-Induced Insulin Resistance and Inflammation Through Adipose Tissue Remodeling File File

Lee, Hwan Hee , Jeong, Gyu Won , Ye, Byeong Jin , Yoo, Eun Jin , Son, Keoung Sun , Kim, Dong Ki , Park, Hye-Kyung , Kang, Byoung Heon , Lee-Kwon, Whaseon , Kwon, Hyug Moo , et al

Article Issue Date2022-12 View26

Transcriptional regulation of mitochondrial chaperone TRAP1

Park, MinA , Kim, So Yeon , Kang, Byoung Heon

Conference Paper Issue Date2019-06-19 View5

Transcriptional regulation of mitochondrial stress signal in glioblastoma stem cell

박민아 , 강병헌

Conference Paper Issue Date2018-11-07 View4

TRAP1 Inhibition Increases Glutamine Synthetase Activity in Glutamine Auxotrophic Non-small Cell Lung Cancer Cells File

Vo, Vu T. A. , Choi, Jong-Whan , Phan, Ai N. H. , Hua, Tuyen N. M. , Kim, Min-Kyu , Kang, Byoung Heon , Jung, Soon-Hee , Yong, Suk-Joong , Jeong, Yangsik

Article Issue Date2018-04 View16

TRAP1 is important to maintain stem characteristics of glioma stem cell

박혜경 , 강병헌

Conference Paper Issue Date2018-11-07 View4

TRAP1 maintains stem characteristics of glioma stem cells

박혜경 , Kang, Byoung Heon

Conference Paper Issue Date2018-08-16 View8

TRAP1 regulate the mitochondrial ATPase Inhibitory Factor 1 activity in glioblastoma under hypoxic environment

Kim, So yeon , Park, Min-A , Kang, Byoung Heon

Conference Paper Issue Date2017-05-18 View6

TRAP1 regulation of mitochondrial life or death decision in cancer cells and mitochondria-targeted TRAP1 inhibitors File File

Kang, Byoung Heon

Article Issue Date2012-01 View50

TRAP1 regulation of mitochondrial protein homeostasis

Kang, Byoung Heon

Conference Paper Issue Date2021-12-10 View3

TRAP1 선택적 억제제로서의 화합물 및 이를 포함하는 암 예방 또는 치료용 조성물

강병헌 , 윤남구 , 강수성 , 박은선 , 양수재

Patent Issue Date View7

TRAP1 저해제로서 유용한 화합물 및 이를 포함하는 항암용 조성물

강병헌 , 박혜경 , 이창욱 , 이원석 , 이지훈 , 홍기범 , 김다롱 , 강수성

Patent Issue Date View12

TRAP1, a mitochondrial Hsp90 paralog, maintains stem characteristics of glioma stem cells.

박혜경 , Kang, Byoung Heon

Conference Paper Issue Date2018-04-23 View6

Treatment Chemo-resistant Acute Myeloid Leukemia by Targeting Mitochondrial Activity

Hu, Sung , Park, Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2023-02-22 View8

Treatment relapse/refractory acute myeloid leukemia through mitochondria target therapy

Hu, Sung , Park, Hye-kyung , Park, Suyeon , Kang, Byoung Heon

Conference Paper Issue Date2023-09-21 View4

Triphenylphosphonium conjugation to a TRAP1 inhibitor, 2-amino-6--chloro-7,9-dihydro-8H-purin-8-one increases antiproliferative activity File

Yang, Sujae , Yoon, Nam Gu , Park, Min-A , Yun, Jisu , Im, Jin Young , Kang, Byoung Heon , Kang, Soosung

Article Issue Date2022-09 View24

Tumor Necrosis Factor Receptor Associated Protein 1 (TRAP1) Regulates Single-Strand DNA Binding Protein 1 (SSBP1) To Help Mitochondria Integrity

Lee, JH , Kim, So Yeon , Kang, Byoung Heon

Conference Paper Issue Date2022-09-29 View8

Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1 File File

Park, Hye-Kyung , Yoon, Nam Gu , Lee, Ji-Eun , Hu, Sung , Yoon, Sora , Kim, So Yeon , Hong, Jun-Hee , Nam, Dougu , Chae, Young Chan , Park, Jong Bae , et al

Article Issue Date2020-01 View25

독소루비신 및 개미트리닙을 유효성분으로 포함하는 암 치료용 약학 조성물

강병헌 , 박혜경 , 이지은

Patent Issue Date View20

미토콘드리아 내부 축적이 증가된 TRAP1 선택적 억제제로서의 화합물 및 이의 용도

강병헌 , 강수성 , 양수재 , 윤지수 , 박민아

Patent Issue Date View10

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