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Ko, Myunggon (고명곤)

Department
Department of Biological Sciences(생명과학과)
Website
https://myunggonko.wixsite.com/mgko
Lab
Cancer Epigenetics Lab. (종양후생유전학 연구실)
Research Keywords
Leukemia, hematopoiesis, obesity, diabetes, metabolic disease, cancer therapy, cancer
Research Interests
How do alterations in epigenetic landscape disturb the barrier between normal and malignant states to cause cancers? How can we translate these cancer-related aberrations into more efficient cancer therapy? These are two overarching questions that our research is currently addressing. The intricate interplay between genetic and epigenetic pathways plays key roles in regulating normal and malignant cellular development.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2022-04BAP1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cellsJeong, Jinguk; Jung, Inkyung; Kim, Ji-Hoon, et alARTICLE7 BAP1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cells
2021-11Rapid and Label-Free Detection of 5-Hydroxymethylcytosine in Genomic DNA Using an Au/ZnO Nanorods Hybrid Nanostructure-Based Electrochemical SensorBhat, Kiesar Sideeq; Kim, Hyejin; Alam, Asrar, et alARTICLE213 Rapid and Label-Free Detection of 5-Hydroxymethylcytosine in Genomic DNA Using an Au/ZnO Nanorods Hybrid Nanostructure-Based Electrochemical Sensor
2020-12Direct and rapid detection of 5-hydroxymethylcytosine, a novel cancer hallmark in DNA, using electrochemical reactionLee, Seo Yeon; Qi, Xu; Ko, Myunggon, et alARTICLE435 Direct and rapid detection of 5-hydroxymethylcytosine, a novel cancer hallmark in DNA, using electrochemical reaction
2020-06Decoding ribosomes to keep growing (in AML)An, Jungeun; Ko, MyunggonARTICLE224 Decoding ribosomes to keep growing (in AML)
2020-05Decreased vitamin C uptake mediated by SLC2A3 promotes leukaemia progression and impedes TET2 restorationLiu, Jun; Hong, Junshik; Han, Heejoo, et alARTICLE291 Decreased vitamin C uptake mediated by SLC2A3 promotes leukaemia progression and impedes TET2 restoration
2017-04TET family dioxygenases and DNA demethylation in stem cells and cancersAn, Jungeun; Rao, Anjana; Ko, MyunggonARTICLE723 TET family dioxygenases and DNA demethylation in stem cells and cancers
2016-12DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA MethyltransferasesNair, Varun Sasidharan; Song, Mi Hye; Ko, Myunggon, et alARTICLE757 DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA Methyltransferases
2016-09DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cellsZhang, Xiaotian; Su, Jianzhong; Jeong, Mira, et alARTICLE980 DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells
2016-05TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic ActivitiesMontagner, Sara; Leoni, Cristina; Emming, Stefan, et alARTICLE762 TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities
2015-12DNA methylation and hydroxymethylation in hematologic differentiation and transformationKo, Myunggon; An, Jungeun; Rao, AnjanaARTICLE1282 DNA methylation and hydroxymethylation in hematologic differentiation and transformation
2015-11Acute loss of TET function results in aggressive myeloid cancer in miceAn, Jungeun; Gonzalez-Avalos, E.; Chawla, Ashu, et alARTICLE980 Acute loss of TET function results in aggressive myeloid cancer in mice
2015-11Functions of TET Proteins in Hematopoietic TransformationHan, Jae-A; An, Jungeun; Ko, MyunggonARTICLE920 Functions of TET Proteins in Hematopoietic Transformation
2015-03A zebrafish model of myelodysplasia produced through tet2 genomic editingGjini, Evisa; Mansour, Marc R; Sander, Jeffry D, et alARTICLE1337 A zebrafish model of myelodysplasia produced through tet2 genomic editing
2015-01TET proteins and 5-methylcytosine oxidation in hematological cancersKo, Myunggon; An, Jungeun; Pastor, William A., et alARTICLE1018 TET proteins and 5-methylcytosine oxidation in hematological cancers
2014-01Large conserved domains of low DNA methylation maintained by 5-hydroxymethycytosine and Dnmt3aJeong, Mira; Sun, Deqiang; Luo, Min, et alARTICLE965 Large conserved domains of low DNA methylation maintained by 5-hydroxymethycytosine and Dnmt3a
2013-05Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAXKo, Myunggon; An, Jungeun; Bandukwala, Hozefa S, et alARTICLE817 Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX
2012-09D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane functionSasaki, Masato; Knobbe, Christiane B; Itsumi, Momoe, et alARTICLE907 D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function
2012-04The SWI/SNF-like BAF complex is essential for early B cell developmentChoi, Jinwook; Ko, Myunggon; Jeon, Shin, et alARTICLE949 The SWI/SNF-like BAF complex is essential for early B cell development
2011-10TET2: epigenetic safeguard for HSCKo, Myunggon; Rao, AnjanaARTICLE738 TET2: epigenetic safeguard for HSC
2011-08Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in miceKo, Myung Gon; Bandukwala, Hozefa S; An, Jungeun, et alARTICLE831 Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

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