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Ko, Myunggon (고명곤)

Department: Department of Biological Sciences(생명과학과)

Website: https://myunggonko.wixsite.com/mgko

Lab: Cancer Epigenetics Lab. (종양후생유전학 연구실)

Research Keywords: Leukemia, hematopoiesis, obesity, diabetes, metabolic disease, cancer therapy, cancer

Research Interests: How do alterations in epigenetic landscape disturb the barrier between normal and malignant states to cause cancers? How can we translate these cancer-related aberrations into more efficient cancer therapy? These are two overarching questions that our research is currently addressing. The intricate interplay between genetic and epigenetic pathways plays key roles in regulating normal and malignant cellular development.

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Issue Date	Title	Author(s)	Type	View	Altmetrics
2020-12	Direct and rapid detection of 5-hydroxymethylcytosine, a novel cancerhallmark in DNA, using electrochemical reaction	Lee, Seo Yeon; Qi, Xu; Ko, Myunggon, et al	ARTICLE	67	Direct and rapid detection of 5-hydroxymethylcytosine, a novel cancerhallmark in DNA, using electrochemical reaction
2020-06	Decoding ribosomes to keep growing (in AML)	An, Jungeun; Ko, Myunggon	ARTICLE	69	Decoding ribosomes to keep growing (in AML)
2020-03	Decreased vitamin C uptake mediated by SLC2A3 promotes leukaemia progression and impedes TET2 restoration	Liu, Jun; Hong, Junshik; Han, Heejoo, et al	ARTICLE	104	Decreased vitamin C uptake mediated by SLC2A3 promotes leukaemia progression and impedes TET2 restoration
2017-04	TET family dioxygenases and DNA demethylation in stem cells and cancers	An, Jungeun; Rao, Anjana; Ko, Myunggon	ARTICLE	494	TET family dioxygenases and DNA demethylation in stem cells and cancers
2016-12	DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA Methyltransferases	Nair, Varun Sasidharan; Song, Mi Hye; Ko, Myunggon, et al	ARTICLE	561	DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA Methyltransferases
2016-09	DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells	Zhang, Xiaotian; Su, Jianzhong; Jeong, Mira, et al	ARTICLE	682	DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells
2016-05	TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities	Montagner, Sara; Leoni, Cristina; Emming, Stefan, et al	ARTICLE	576	TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities
2015-12	DNA methylation and hydroxymethylation in hematologic differentiation and transformation	Ko, Myunggon; An, Jungeun; Rao, Anjana	ARTICLE	1074	DNA methylation and hydroxymethylation in hematologic differentiation and transformation
2015-11	Acute loss of TET function results in aggressive myeloid cancer in mice	An, Jungeun; Gonzalez-Avalos, E.; Chawla, Ashu, et al	ARTICLE	767	Acute loss of TET function results in aggressive myeloid cancer in mice
2015-11	Functions of TET Proteins in Hematopoietic Transformation	Han, Jae-A; An, Jungeun; Ko, Myunggon	ARTICLE	728	Functions of TET Proteins in Hematopoietic Transformation
2015-03	A zebrafish model of myelodysplasia produced through tet2 genomic editing	Gjini, Evisa; Mansour, Marc R; Sander, Jeffry D, et al	ARTICLE	1041	A zebrafish model of myelodysplasia produced through tet2 genomic editing
2015-01	TET proteins and 5-methylcytosine oxidation in hematological cancers	Ko, Myunggon; An, Jungeun; Pastor, William A., et al	ARTICLE	806	TET proteins and 5-methylcytosine oxidation in hematological cancers
2014-01	Large conserved domains of low DNA methylation maintained by 5-hydroxymethycytosine and Dnmt3a	Jeong, Mira; Sun, Deqiang; Luo, Min, et al	ARTICLE	681	Large conserved domains of low DNA methylation maintained by 5-hydroxymethycytosine and Dnmt3a
2013-05	Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX	Ko, Myunggon; An, Jungeun; Bandukwala, Hozefa S, et al	ARTICLE	621	Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX
2012-09	D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function	Sasaki, Masato; Knobbe, Christiane B; Itsumi, Momoe, et al	ARTICLE	688	D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function
2012-04	The SWI/SNF-like BAF complex is essential for early B cell development	Choi, Jinwook; Ko, Myunggon; Jeon, Shin, et al	ARTICLE	703	The SWI/SNF-like BAF complex is essential for early B cell development
2011-10	TET2: epigenetic safeguard for HSC	Ko, Myunggon; Rao, Anjana	ARTICLE	552	TET2: epigenetic safeguard for HSC
2011-08	Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice	Ko, Myung Gon; Bandukwala, Hozefa S; An, Jungeun, et al	ARTICLE	634	Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
2011-05	Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells	Pastor, William A; Pape, Utz J; Huang, Yun, et al	ARTICLE	779	Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
2011-01	Srg3 is a novel p53 target and acts as a tumor suppressor by modulating p21WAF1/CIP1 expression	Ahn, Jungeun; Ko, Myung Gon; Lee, Changjin, et al	ARTICLE	724	Srg3 is a novel p53 target and acts as a tumor suppressor by modulating p21WAF1/CIP1 expression

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