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Lim, Chunghun
Neurogenetics & Ribonomics Laboratory (The Lim Lab)
Research Interests
  • Ribosome Biology, Translation, Neurodegeneration, Behavioral Genetics

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The Kaposi's sarcoma-associated herpesvirus K8 protein interacts with CREB-binding protein (CBP) and represses CBP-mediated transcription

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Title
The Kaposi's sarcoma-associated herpesvirus K8 protein interacts with CREB-binding protein (CBP) and represses CBP-mediated transcription
Author
Hwang, SEUNGMINGwack, YOUSANGByun, HYEWONLim, ChunghunChoe, JOONHO
Issue Date
2001-10
Publisher
AMER SOC MICROBIOLOGY
Citation
JOURNAL OF VIROLOGY, v.75, no.19, pp.9509 - 9516
Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame K8 encodes a basic region-leucine zipper protein of 237 amino acids that homodimerizes with its bZIP domain. KSHV K8 shows significant homology to the Epstein-Barr virus (EBV) immediate-early protein Zta, a key regulator in the reactivation and replication of EBV. In this study, we report that K8, like its homolog EBV Zta, interacts with cellular CREB-binding protein (CBP) in vivo and in vitro. This interaction requires the C/H3 domain of CBP and the basic region of K8. K8 represses CBP-mediated transcription by competing with limited amounts of cellular CBP, exemplified by the reduced expression from the AP-1 and human immunodeficiency virus long terminal repeat promoters.
URI
https://scholarworks.unist.ac.kr/handle/201301/9898
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0034842669
DOI
10.1128/JVI.75.19.9509-9516.2001
ISSN
0022-538X
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BIO_Journal Papers
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