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Joo, Sang Hoon
Nanomaterials & Catalysis Lab
Research Interests
  • Catalyst, energy conversion, fuel cells, electrolyzer, ORR, HER, OER

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Noncovalent Polymer-Gatekeeper in Mesoporous Silica Nanoparticles as a Targeted Drug Delivery Platform

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Title
Noncovalent Polymer-Gatekeeper in Mesoporous Silica Nanoparticles as a Targeted Drug Delivery Platform
Author
Palanikumar, L.Choi, Eun SeongCheon, Jae YeongJoo, Sang HoonRyu, Ja-Hyoung
Issue Date
2015-02
Publisher
WILEY-V C H VERLAG GMBH
Citation
ADVANCED FUNCTIONAL MATERIALS, v.25, no.6, pp.957 - 965
Abstract
Selective targeting of tumor cells and release of drug molecules inside the tumor microenvironment can reduce the adverse side effects of traditional chemotherapeutics because of the lower dosages required. This can be achieved by using stimuli-responsive targeted drug delivery systems. In the present work, a robust and simple one-pot route is developed to synthesize polymer-gatekeeper mesoporous silica nanoparticles by noncovalent capping of the pores of drug-loaded nanocontainers with disulfide cross-linkable polymers. The method offers very high loading efficiency because chemical modification of the mesoporous nanoparticles is not required; thus, the large empty pore volume of pristine mesoporous silica nanoparticles is entirely available to encapsulate drug molecules. Furthermore, the polymer shell can be easily decorated with a targeting ligand for selective delivery to specific cancer cells by subsequent addition of the thiol-containing ligand molecule. The drug molecules loaded in the nanocontainers can be released by the degradation of the polymer shell in the intracellular reducing microenvironment, which consequentially induces cell death.
URI
https://scholarworks.unist.ac.kr/handle/201301/9885
URL
https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201402755
DOI
10.1002/adfm.201402755
ISSN
1616-301X
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PHY_Journal Papers
ECHE_Journal Papers
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