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Lim, Chunghun
Neurogenetics & Ribonomics Laboratory (The Lim Lab)
Research Interests
  • Ribosome Biology, Translation, Neurodegeneration, Behavioral Genetics

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clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila

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Title
clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila
Author
Lim, ChunghunChung, Brian Y.Pitman, Jena L.McGill, Jermaine J.Pradhan, SurajLee, JongbinKeegan, Kevin P.Choe, JoonhoAllada, Ravi
Issue Date
2007-06
Publisher
CELL PRESS
Citation
CURRENT BIOLOGY, v.17, no.12, pp.1082 - 1089
Abstract
Gene transcription is a central timekeeping process in animal clocks. In Drosophila, the basic helix-loop helix (bHLH)-PAS transcription-factor heterodimer, CLOCK/CYCLE (CLK/CYC), transcriptionally activates the clock components period (per), timeless (tim), Par domain protein 1 (Pdp1), and vrille (vri), which feed back and regulate distinct features of CLK/CYC function [1]. Microarray studies have identified numerous rhythmically expressed transcripts [2-7], some of which are potential direct CLK targets [7]. Here we demonstrate a circadian function for one such target, a bHLH-Orange repressor, CG17100/CLOCKWORK ORANGE (CWO). cwo is rhythmically expressed, and levels are reduced in Clk mutants, suggesting that cwo is CLK activated in vivo. cwo mutants display reduced-amplitude molecular and behavioral rhythms with lengthened periods. Molecular analysis suggests that CWO acts, in part, by repressing CLK target genes. We propose that CWO acts as a transcriptional and behavioral rhythm amplifier.
URI
https://scholarworks.unist.ac.kr/handle/201301/9833
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34250215964
DOI
10.1016/j.cub.2007.05.039
ISSN
0960-9822
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