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Lim, Chunghun
Neurogenetics & Ribonomics Laboratory (The Lim Lab)
Research Interests
  • Ribosome Biology, Translation, Neurodegeneration, Behavioral Genetics

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Functional role of CREB-binding protein in the circadian clock system of Drosophila melanogaster

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Title
Functional role of CREB-binding protein in the circadian clock system of Drosophila melanogaster
Author
Lim, ChunghunLee, JongbinChoi, ChangtaekKim, JuwonDoh, EunjinChoe, Joonho
Issue Date
2007-07
Publisher
AMER SOC MICROBIOLOGY
Citation
MOLECULAR AND CELLULAR BIOLOGY, v.27, no.13, pp.4876 - 4890
Abstract
Rhythmic histone acetylation underlies the oscillating expression of clock genes in the mammalian circadian clock system. Cellular factors that contain histone acetyltransferase and histone deacetylase activity have been implicated in these processes by direct interactions with clock genes, but their functional relevance remains to be assessed by use of appropriate animal models. Here, using transgenic fly models, we show that CREBbinding protein (CBP) participates in the transcriptional regulation of the Drosophila CLOCK/CYCLE (dCLK/ CYC) heterodimer. CBP knockdown in pigment dispersing factor-expressing cells lengthens the period of adult locomotor rhythm with the prolonged expression of period and timeless genes, while CBP overexpression in timeless-expressing cells causes arrhythmic circadian behaviors with the impaired expression of these dCLK/ CYC-induced clock genes. In contrast to the mammalian circadian clock system, CBP overexpression attenuates the transcriptional activity of the dCLK/CYC heterodimer in cultured cells, possibly by targeting the PER-ARNT-SIM domain of dCLK. Our data suggest that the Drosophila circadian clock system has evolved a distinct mechanism to tightly regulate the robust transcriptional potency of the dCLK/CYC heterodimer.
URI
https://scholarworks.unist.ac.kr/handle/201301/9818
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34347332369
DOI
10.1128/MCB.02155-06
ISSN
0270-7306
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