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DC Field | Value | Language |
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dc.citation.endPage | 1687 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1683 | - |
dc.citation.title | ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS | - |
dc.citation.volume | 70 | - |
dc.contributor.author | Kang, Byoung Heon | - |
dc.contributor.author | Jeong, Hanbin | - |
dc.contributor.author | Lee, Changwook | - |
dc.date.accessioned | 2023-12-22T01:48:59Z | - |
dc.date.available | 2023-12-22T01:48:59Z | - |
dc.date.created | 2014-12-31 | - |
dc.date.issued | 2014-12 | - |
dc.description.abstract | Hsp90 is a molecular chaperone responsible for the assembly and regulation of many cellular client proteins. In particular, Trap1, a mitochondrial Hsp90 homologue, plays a pivotal role in maintaining mitochondrial integrity, protecting against apoptosis in cancer cells. The N (N-terminal)-M (middle) domain of human Trap1 was crystallized in complex with Hsp90 inhibitors (PU-H71 and BIIB-021) by the hanging-drop vapour-diffusion method at pH 6.5 and 293 K using 15% PEG 8K as a precipitant. Diffraction data were collected from crystals of the Trap1-PU-H71 (2.7 A) and Trap1-BIIB-021 (3.1 A) complexes to high resolution at a synchrotron-radiation source. Preliminary X-ray diffraction analysis revealed that both crystals belonged to space group P41212 or P43212, with unit-cell parameters a = b = 69.2, c = 252.5 A, and contained one molecule per asymmetric unit according to Matthews coefficient calculations. | - |
dc.identifier.bibliographicCitation | ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, v.70, no.12, pp.1683 - 1687 | - |
dc.identifier.doi | 10.1107/S2053230X14024959 | - |
dc.identifier.issn | 2053-230X | - |
dc.identifier.scopusid | 2-s2.0-84925884404 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/9783 | - |
dc.identifier.url | http://scripts.iucr.org/cgi-bin/paper?S2053230X14024959 | - |
dc.identifier.wosid | 000345843300025 | - |
dc.language | 영어 | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Crystallization and preliminary X-ray diffraction analysis of Trap1 complexed with Hsp90 inhibitors | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods; Biochemistry & Molecular Biology; Biophysics; Crystallography | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Biophysics; Crystallography | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | CHAPERONE MACHINERY | - |
dc.subject.keywordPlus | MITOCHONDRIAL HSP90 | - |
dc.subject.keywordPlus | PROTECTS CELLS | - |
dc.subject.keywordPlus | CONFORMATION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | EVOLUTION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | INSIGHTS | - |
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