BROWSE

Related Researcher

Author's Photo

Bhak, Jong
KOrean GenomIcs Center(KOGIC)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS

ITEM VIEW & DOWNLOAD

Mutational hotspots in the mitochondrial genome of lung cancer

Cited 6 times inthomson ciCited 5 times inthomson ci
Title
Mutational hotspots in the mitochondrial genome of lung cancer
Author
Choi, So-JungKim, Sung-HyunKang, Ho Y.Lee, JinseonBhak, Jong HwaSohn, InsukJung, Sin-HoChoi, Yong SooKim, Hong KwanHan, JunghoHuh, NamLee, GyusangKim, Byung C.Kim, Jhingook
Keywords
10398; 8701; DCA; Lung cancer; Mitochondrial mutation; Smoking
Issue Date
2011-04
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.407, no.1, pp.23 - 27
Abstract
We determined the somatic mutations in the mitochondrial genomes of 70 lung cancer patients by pair-wise comparative analyses of the normal- and tumor-genome sequences acquired using Affymetrix Mitochondrial Resequencing Array 2.0. The overall mutation rates in lung cancers were Approximately 100 fold higher than those in normal cells, with significant statistical correlation with smoking (p = 0.00088). Total of 532 somatic mutations were evenly distributed in 499 positions with very low overall frequency (1.07/bp), but the non-synonymous mutations causing amino acid substitution occurred more frequently (1.83/bp), particularly at two positions, 8701 and 10398 (10.5/bp) that code for ATPase6 and NADH dehydrogenase 3, respectively. Despite the randomness or even distribution of the mutations, these two mutations occurred together in 86% of the cases. The linkage between the two most frequent mutations suggests that they were selected together, possibly due to their cooperative role during cancer development. Indeed, the mutation at 10398 was shown by Canter, Pezzotti, and their colleagues in 2009, as a risk factor for breast cancer. In this study, we identified two potential biomarkers that might be functionally linked together during the development of cancer.
URI
Go to Link
DOI
10.1016/j.bbrc.2011.02.078
ISSN
0006-291X
Appears in Collections:
BME_Journal Papers
Files in This Item:
2-s2.0-79953163479.pdf Download

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU