BROWSE

Related Researcher

Author's Photo

Bhak, Jong
KOrean GenomIcs Center(KOGIC)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS

ITEM VIEW & DOWNLOAD

The tiger genome and comparative analysis with lion and snow leopard genomes

Cited 14 times inthomson ciCited 11 times inthomson ci
Title
The tiger genome and comparative analysis with lion and snow leopard genomes
Author
Cho, Yun SungHu, LiHou, HaolongLee, HangXu, JiaohuiKwon, SoowhanOh, SukhunKim, Hak-MinJho, SungwoongKim, SangsooShin, Young-AhKim, Byung ChulKim, HyunminKim, Chang-ukLuo, Shu-JinJohnson, Warren E.Koepfli, Klaus-PeterSchmidt-Kuentzel, AnneTurner, Jason A.Marker, LaurieHarper, CindyMiller, Susan M.Jacobs, WilhelmBertola, Laura D.Kim, Tae HyungLee, SunghoonZhou, QianJung, Hyun-JuXu, XiaoGadhvi, PriyvratXu, PengweiXiong, YingqiLuo, YadanPan, ShengkaiGou, CaiyunChu, XiuhuiZhang, JilinLiu, SanyangHe, JingChen, YingYang, LinfengYang, YulanHe, JiajuLiu, ShaWang, JunyiKim, Chul HongKwak, HwanjongKim, Jong-SooHwang, SeungwooKo, JunsuKim, Chang-BaeKim, SangtaeBayarlkhagva, DamdinPaek, Woon KeeKim, Seong-JinO'Brien, Stephen J.Wang, JunBhak, Jong Hwa
Keywords
INITIAL SEQUENCE; TASMANIAN DEVIL; HIGH-ALTITUDE; ALIGNMENT; ADAPTATION; INSIGHTS; DATABASE; TOOL; CONSERVATION; TRANSCRIPTS
Issue Date
2013-09
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE COMMUNICATIONS, v.4, no., pp. -
Abstract
Tigers and their close relatives (Panthera) are some of the world's most endangered species. Here we report the de novo assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal tiger, African lion, white African lion and snow leopard. Through comparative genetic analyses of these genomes, we find genetic signatures that may reflect molecular adaptations consistent with the big cats' hypercarnivorous diet and muscle strength. We report a snow leopard-specific genetic determinant in EGLN1 (Met39>Lys39), which is likely to be associated with adaptation to high altitude. We also detect a TYR260G>A mutation likely responsible for the white lion coat colour. Tiger and cat genomes show similar repeat composition and an appreciably conserved synteny. Genomic data from the five big cats provide an invaluable resource for resolving easily identifiable phenotypes evident in very close, but distinct, species.
URI
Go to Link
DOI
10.1038/ncomms3433
ISSN
2041-1723
Appears in Collections:
BME_Journal Papers
Files in This Item:
2-s2.0-84892877574.pdf Download

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU